Gene Expression Literature Summary

• Symbol: Dkk4
• Name: dickkopf WNT signaling pathway inhibitor 4
• ID: MGI:2385299

40 matching records from 40 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E3	E3.5	E5.5	E6.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E	P
In situ RNA (section)												1	1	1	3	4		9	1	4	3	1	1	1	1	2
In situ RNA (whole mount)											2	1	3	1	5	3	5	8	2		1	1
In situ reporter (knock in)																										1
Western blot																				1		1	1	1
RT-PCR	1	1	1	1	1	2	1	1	1	1		1	1		4	4	1	3		5		2	1	2		1
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dkk4  dickkopf WNT signaling pathway inhibitor 4   (Synonyms: MGC:25705)
Results	Reference
1	J:194074 Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R, Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
19	J:121612 Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM, The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis. Dev Biol. 2007 May 15;305(2):498-507
1	J:183485 Chen D, Jarrell A, Guo C, Lang R, Atit R, Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012 Apr;139(8):1522-33
4	J:111051 Cui CY, Hashimoto T, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D, Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142-7
4	J:217500 Cui CY, Yin M, Sima J, Childress V, Michel M, Piao Y, Schlessinger D, Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014 Oct;141(19):3752-60
5*	J:94639 Diep DB, Hoen N, Backman M, Machon O, Krauss S, Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain. Brain Res Dev Brain Res. 2004 Nov 25;153(2):261-70
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:252728 Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML, Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Sci Rep. 2017 Jul 11;7(1):5049
2	J:178994 Fantauzzo KA, Christiano AM, Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012 Jan;139(1):203-14
4	J:138365 Fliniaux I, Mikkola ML, Lefebvre S, Thesleff I, Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes. Dev Biol. 2008 Aug 1;320(1):60-71
1	J:196515 Fu J, Hsu W, Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol. 2013 Apr;133(4):890-8
2*	J:244781 Glover JD, Wells KL, Matthaus F, Painter KJ, Ho W, Riddell J, Johansson JA, Ford MJ, Jahoda CAB, Klika V, Mort RL, Headon DJ, Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS Biol. 2017 Jul;15(7):e2002117
7*	J:122362 Harwood BN, Cross SK, Radford EE, Haac BE, de Vries WN, Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Dev Dyn. 2008;237(4):1099-1111
1	J:157057 Heath J, Langton AK, Hammond NL, Overbeek PA, Dixon MJ, Headon DJ, Hair follicles are required for optimal growth during lateral skin expansion. J Invest Dermatol. 2009 Oct;129(10):2358-64
2	J:193958 Huh SH, Narhi K, Lindfors PH, Haara O, Yang L, Ornitz DM, Mikkola ML, Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
3	J:208431 Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y, TGFbeta regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb;141(4):909-17
2	J:341969 Jacob T, Annusver K, Czarnewski P, Dalessandri T, Kalk C, Levra Levron C, Campama Sanz N, Kastriti ME, Mikkola ML, Rendl M, Lichtenberger BM, Donati G, Bjorklund AK, Kasper M, Molecular and spatial landmarks of early mouse skin development. Dev Cell. 2023 Oct 23;58(20):2140-2162.e5
1	J:258789 Jarvinen E, Shimomura-Kuroki J, Balic A, Jussila M, Thesleff I, Mesenchymal Wnt/beta-catenin signaling limits tooth number. Development. 2018 Feb 21;145(4):dev158048
2	J:239871 Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I, Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15;142(22):3954-63
5*	J:98792 Kemp C, Willems E, Abdo S, Lambiv L, Leyns L, Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn. 2005 May 5;233(3):1064-1075
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:185240 Lefebvre S, Fliniaux I, Schneider P, Mikkola ML, Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012 Apr;132(4):1094-102
3	J:255610 Li C, Lan Y, Krumlauf R, Jiang R, Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. J Dent Res. 2017 Oct;96(11):1273-1281
2	J:278227 Li H, Jones KL, Hooper JE, Williams T, The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution. Development. 2019 Jun 17;146(12):dev174888
1	J:324116 Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H, Tracing the origin of hair follicle stem cells. Nature. 2021 Jun;594(7864):547-552
1*	J:281804 Mou C, Thomason HA, Willan PM, Clowes C, Harris WE, Drew CF, Dixon J, Dixon MJ, Headon DJ, Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form. Hum Mutat. 2008 Dec;29(12):1405-11
1*	J:186534 Porntaveetus T, Ohazama A, Choi HY, Herz J, Sharpe PT, Wnt signaling in the murine diastema. Eur J Orthod. 2012 Aug;34(4):518-24
1	J:168016 Reid BS, Yang H, Melvin VS, Taketo MM, Williams T, Ectodermal Wnt/beta-catenin signaling shapes the mouse face. Dev Biol. 2011 Jan 15;349(2):261-9
2	J:238111 Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML, Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. Stem Cells. 2016 Jul;34(7):1896-908
1	J:253067 Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF, Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455
7	J:237499 Sima J, Piao Y, Chen Y, Schlessinger D, Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development. 2016 Dec 15;143(24):4723-4735
1	J:270947 Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE, Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. Cell Rep. 2018 Dec 11;25(11):2981-2991.e3
2*	J:338194 Sulic AM, Das Roy R, Papagno V, Lan Q, Saikkonen R, Jernvall J, Thesleff I, Mikkola ML, Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643
2*	J:155223 Suomalainen M, Thesleff I, Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. Dev Dyn. 2009 Oct 5;239(1):364-372
1	J:324119 Van Otterloo E, Milanda I, Pike H, Thompson JA, Li H, Jones KL, Williams T, AP-2alpha and AP-2beta cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development. Elife. 2022 Mar 25;11:e70511
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:231699 Voutilainen M, Lindfors PH, Trela E, Lonnblad D, Shirokova V, Elo T, Rysti E, Schmidt-Ullrich R, Schneider P, Mikkola ML, Ectodysplasin/NF-kappaB Promotes Mammary Cell Fate via Wnt/beta-catenin Pathway. PLoS Genet. 2015 Nov;11(11):e1005676
6*	J:146657 Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S, Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23
2	J:151982 Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R, Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009 Jul;17(1):49-61
2	J:146244 Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT, Hafen K, Tsukamoto N, Amagai T, Taketo MM, Krenger W, Hollander GA, Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol. 2009 Mar 1;182(5):2997-3007