About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178

31 matching records from 31 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3.5 E6.5 E7 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E18.5 E19.5 A
In situ protein (section) 1
In situ RNA (section) 1 1 1 1 3 2
In situ RNA (whole mount) 1 1 1 1 1 2
Northern blot 1 1 1 1 2
Western blot 2 2 1 2 1 1 1 4
RT-PCR 1 1 1 1 1 1 1 1 1 2 2 3 1 3 1 1 1 7
cDNA clones 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Dicer1  dicer 1, ribonuclease type III   (Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1, mKIAA0928)
Results  Reference
3J:176638 Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC, MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1118-26
2J:110268 Andl T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE, The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006 May 23;16(10):1041-9
1J:200017 Barritt LC, Miller JM, Scheetz LR, Gardner K, Pierce ML, Soukup GA, Rocha-Sanchez SM, Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development. Indian J Hum Genet. 2012 Sep;18(3):310-9
2J:164021 Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A, Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One. 2010;5(8):e12450
1J:183920 Chen J, Lai F, Niswander L, The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
1J:131962 Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
9J:203415 Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P, A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell. 2013 Nov 7;155(4):807-16
2J:108137 Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I, Genomic imprinting in Dicer1-hypomorphic mice. Cytogenet Genome Res. 2006;113(1-4):138-43
3J:106072 Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X, Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2208-13
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2J:182094 Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ, Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2575-86
4J:153666 Kawase-Koga Y, Otaegi G, Sun T, Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn. 2009 Nov;238(11):2800-12
1J:131828 Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM, Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1949-54
2J:151925 Li Y, Piatigorsky J, Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. Dev Dyn. 2009 Sep;238(9):2388-400
2*J:99751 Lu J, Qian J, Chen F, Tang X, Li C, Cardoso WV, Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophys Res Commun. 2005 Aug 26;334(2):319-23
1J:132315 Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS, MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007 Dec;56(12):2938-45
3J:160269 Michon F, Tummers M, Kyyronen M, Frilander MJ, Thesleff I, Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs. Dev Biol. 2010 Apr 15;340(2):355-68
3*J:74999 Nicholson RH, Nicholson AW, Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference. Mamm Genome. 2002 Feb;13(2):67-73
1J:197985 Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K, ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
2J:123635 Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, Kang YJ, Jiang Z, Du X, Cook R, Das SC, Pattnaik AK, Beutler B, Han J, Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007 Jul;27(1):123-34
1J:172088 Pan Y, Balazs L, Tigyi G, Yue J, Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011 May 13;408(3):369-74
2J:188279 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N, A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation. J Neurosci. 2012 Sep 19;32(38):13292-13308
1J:188151 Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M, Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
1J:194793 Rosengauer E, Hartwich H, Hartmann AM, Rudnicki A, Satheesh SV, Avraham KB, Nothwang HG, Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of Mammalian central auditory nuclei. PLoS One. 2012;7(11):e49503
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
8*J:97770 Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G, Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330-5
1J:166872 Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA, MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010 Nov 5;285(45):34718-28
2J:170604 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X, The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory