Gene Expression Literature Summary

• Symbol: Sirt1
• Name: sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
• ID: MGI:2135607

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E3	E3.5	E4.5	E5.5	E6.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	A
In situ protein (section)												1	1	2	1	3	2	1		1		2
In situ RNA (section)													1			1	1					2
In situ protein (whole mount)		1																				1
In situ RNA (whole mount)													1
Northern blot						1	1	1	1	1	1	1	1	1	1	1	1	1	2	1		3
Western blot														2		2	1	1		1	2	5
RT-PCR	1	1	1	1	1					1			1	1		1		1				2
cDNA clones																						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sirt1  sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)   (Synonyms: Sir2, Sir2alpha)
Results	Reference
2	J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600
1	J:138789 Hasegawa K, Yoshikawa K, Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci. 2008 Aug 27;28(35):8772-84
5	J:151680 Iwahara N, Hisahara S, Hayashi T, Horio Y, Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. Biochem Biophys Res Commun. 2009 Sep 4;386(4):671-5
6*	J:163766 Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H, Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest. 2010 Aug 2;120(8):2817-28
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:81010 McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M, The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003 Jan;23(1):38-54
7	J:172620 Ogawa T, Wakai C, Saito T, Murayama A, Mimura Y, Youfu S, Nakamachi T, Kuwagata M, Satoh K, Shioda S, Distribution of the longevity gene product, SIRT1, in developing mouse organs. Congenit Anom (Kyoto). 2011 Jun;51(2):70-9
1*	J:100371 Okada A, Kushima K, Aoki Y, Bialer M, Fujiwara M, Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth Defects Res A Clin Mol Teratol. 2005 Apr;73(4):229-38
31*	J:87352 Sakamoto J, Miura T, Shimamoto K, Horio Y, Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. FEBS Lett. 2004 Jan 2;556(1-3):281-6
2	J:180628 Seifert EL, Caron AZ, Morin K, Coulombe J, Hong He X, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW, SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J. 2012 Feb;26(2):555-66
4	J:120915 Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y, Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem. 2007 Mar 2;282(9):6823-32
2	J:140089 Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX, Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008 Oct 7;14(4):312-23
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48