Gene Expression Literature Summary

• Symbol: Elovl4
• Name: ELOVL fatty acid elongase 4
• ID: MGI:1933331

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E10.5	E11	E11.5	E12.5	E14.5	E15	E17	E18	E18.5	P
Immunohistochemistry (section)		1		1	1	1					1
In situ RNA (section)							1			1	2
Northern blot	1		1				1	1			1
Western blot										1
RT-PCR	1		1				1	1	1	5	4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Elovl4  ELOVL fatty acid elongase 4   (Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4)
Results	Reference
1*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:147182 Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK, Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol. 2009 Jun;129(6):1459-70
1	J:317805 Kato A, Ito M, Sanaki T, Okuda T, Tsuchiya N, Yoshimoto R, Yukioka H, Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of omega-O-acylceramide in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159085
1	J:314906 Khang R, Jo A, Kang H, Kim H, Kwag E, Lee JY, Koo O, Park J, Kim HK, Jo DG, Hwang I, Ahn JY, Lee Y, Choi JY, Lee YS, Shin JH, Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
1	J:216600 Lau CG, Marikawa Y, Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
2*	J:255485 Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK, Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427
15*	J:89293 Mandal MN, Ambasudhan R, Wong PW, Gage PJ, Sieving PA, Ayyagari R, Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression. Genomics. 2004 Apr;83(4):626-35
1*	J:286705 Miyamoto M, Itoh N, Sawai M, Sassa T, Kihara A, Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production. J Invest Dermatol. 2020 Feb;140(2):319-326.e4
1*	J:242353 Pichery M, Huchenq A, Sandhoff R, Severino-Freire M, Zaafouri S, Opalka L, Levade T, Soldan V, Bertrand-Michel J, Lhuillier E, Serre G, Maruani A, Mazereeuw-Hautier J, Jonca N, PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. Hum Mol Genet. 2017 May 15;26(10):1787-1800
2*	J:204477 Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A, Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol. 2013 Jul;33(14):2787-96
1	J:346053 Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanovic N, Devkota R, Henn M, Bohlooly-Y M, Hernandez-Hernandez A, Alsheimer M, Boren J, Pilon M, Shibuya H, Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315
2*	J:84734 Zhang XM, Yang Z, Karan G, Hashimoto T, Baehr W, Yang XJ, Zhang K, Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Mol Vis. 2003 Jul 3;9:301-7