Gene Expression Literature Summary

• Symbol: Myh10
• Name: myosin, heavy polypeptide 10, non-muscle
• ID: MGI:1930780

75 matching records from 75 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2.5	E3	E3.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)							2	1	1	4	7	3	14		6	1	9	4	4	3	6	1	3	1	8		1	1	3	13
In situ RNA (section)																	1		1		5		1					1	1	2
Immunohistochemistry (whole mount)	2	2	2	1	1	1				1	1		3	3	1				1					1
In situ RNA (whole mount)													1		1
In situ reporter (knock in)																					2
Northern blot																														1
Western blot													2				1	1	1		1		1		3		1	2	1	10
RT-PCR	1		1	1		1							1					3	1		1		1		2	1		1		7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Myh10  myosin, heavy polypeptide 10, non-muscle   (Synonyms: 5730504C04Rik, 9330167F11Rik, Fltn, Fltn, mKIAA3005, Myhn2, Myhn-2, myosin IIB, Myosin IIB, NMHC-B, NMHC II-B, nonmuscle myosin heavy chain IIB, nonmuscle myosin heavy chain II-B, SMemb)
Results	Reference
3	J:278104 Acebedo AR, Suzuki K, Hino S, Alcantara MC, Sato Y, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein RS, Yamada G, Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice. Commun Biol. 2019;2:95
1	J:277133 Alfano D, Altomonte A, Cortes C, Bilio M, Kelly RG, Baldini A, Tbx1 regulates extracellular matrix-cell interactions in the second heart field. Hum Mol Genet. 2019 Jul 15;28(14):2295-2308
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3	J:266546 Brown JM, Garcia-Garcia MJ, Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development. 2018 Oct 5;145(19):dev170019
1	J:153957 Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA, Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development. 2009 Nov;136(21):3657-67
1*	J:180120 Chauhan BK, Lou M, Zheng Y, Lang RA, Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18289-94
1	J:94940 Conti MA, Even-Ram S, Liu C, Yamada KM, Adelstein RS, Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem. 2004 Oct 1;279(40):41263-6
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:167828 El-Hashash AH, Warburton D, Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011 Feb;240(2):441-5
2	J:335088 Escuin S, Rose Raza-Knight S, Savery D, Gaston-Massuet C, Galea GL, Greene NDE, Copp AJ, Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse. Dis Model Mech. 2023 Mar 1;16(3)
2	J:232964 Escuin S, Vernay B, Savery D, Gurniak CB, Witke W, Greene ND, Copp AJ, Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure. J Cell Sci. 2015 Jul 15;128(14):2468-81
1	J:168569 Garita B, Jenkins MW, Han M, Zhou C, Vanauker M, Rollins AM, Watanabe M, Fujimoto JG, Linask KK, Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart looping. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H879-91
1	J:324294 Goering JP, Wenger LW, Stetsiv M, Moedritzer M, Hall EG, Isai DG, Jack BM, Umar Z, Rickabaugh MK, Czirok A, Saadi I, In-frame deletion of SPECC1L microtubule association domain results in gain-of-function phenotypes affecting embryonic tissue movement and fusion events. Hum Mol Genet. 2021 Dec 17;31(1):18-31
3	J:90427 Golomb E, Ma X, Jana SS, Preston YA, Kawamoto S, Shoham NG, Goldin E, Conti MA, Sellers JR, Adelstein RS, Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. J Biol Chem. 2004 Jan 23;279(4):2800-8
2	J:220469 Grego-Bessa J, Hildebrand J, Anderson KV, Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
1	J:239161 Guo C, Balsara ZR, Hill WG, Li X, Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration. Development. 2017 Feb 01;144(3):400-408
1*	J:166749 Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM 3rd, Levitt P, Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32
3	J:243207 Haque F, Kaku Y, Fujimura S, Ohmori T, Adelstein RS, Nishinakamura R, Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia. Dev Biol. 2017 Jul 01;427(1):121-130
1*	J:331479 Hemkemeyer SA, Liu Z, Vollmer V, Xu Y, Lohmann B, Bahler M, The RhoGAP-myosin Myo9b regulates ocular lens pit morphogenesis. Dev Dyn. 2022 Nov;251(11):1897-1907
1	J:103784 Hildebrand JD, Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J Cell Sci. 2005 Nov 15;118(Pt 22):5191-203
1	J:292950 Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM, GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2018 Mar;29(3):857-868
2	J:289439 Houssin NS, Martin JB, Coppola V, Yoon SO, Plageman TF Jr, Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination. Dev Biol. 2020 Jun 1;462(1):36-49
1	J:83331 Huang H, Paliouras M, Rambaldi I, Lasko P, Featherstone M, Nonmuscle myosin promotes cytoplasmic localization of PBX. Mol Cell Biol. 2003 May;23(10):3636-45
1	J:170883 Huang J, Davis EC, Chapman SL, Budatha M, Marmorstein LY, Word RA, Yanagisawa H, Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res. 2010 Feb 19;106(3):583-92
4*	J:283394 Hughes LJ, Park R, Lee MJ, Terry BK, Lee DJ, Kim H, Cho SH, Kim S, Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation. Dev Biol. 2020 Jan 1;457(1):150-162
1	J:222380 Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, Tsukita S, Tsukita S, Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell. 2008 Jun;19(6):2465-75
1	J:222409 Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO, Convergence and extrusion are required for normal fusion of the mammalian secondary palate. PLoS Biol. 2015 Apr;13(4):e1002122
1	J:89028 Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V, Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004 Mar 1;18(5):559-71
2*	J:213958 Lang RA, Herman K, Reynolds AB, Hildebrand JD, Plageman TF Jr, p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis. Development. 2014 Aug;141(16):3177-87
2	J:199510 Lee J, Andreeva A, Sipe CW, Liu L, Cheng A, Lu X, PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Curr Biol. 2012 Jun 5;22(11):956-66
1*	J:122548 Lee JD, Silva-Gagliardi NF, Tepass U, McGlade CJ, Anderson KV, The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development. 2007 Jun;134(11):2007-16
1	J:310879 Lesko AC, Keller R, Chen P, Sutherland A, Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure. Dev Biol. 2021 Oct;478:59-75
2	J:246153 Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS, N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 Aug 01;428(1):118-134
5	J:142122 Lu W, Seeholzer SH, Han M, Arnold AS, Serrano M, Garita B, Philp NJ, Farthing C, Steele P, Chen J, Linask KK, Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping. Dev Dyn. 2008 Dec;237(12):3577-90
3	J:245570 Ma X, Adelstein RS, A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65
6	J:127463 Ma X, Bao J, Adelstein RS, Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice. Mol Biol Cell. 2007 Jun;18(6):2305-12
3	J:92081 Ma X, Kawamoto S, Hara Y, Adelstein RS, A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons. Mol Biol Cell. 2004 Jun;15(6):2568-79
5	J:112536 Ma X, Kawamoto S, Uribe J, Adelstein RS, Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development. Mol Biol Cell. 2006 May;17(5):2138-49
2	J:247626 Ma X, Sung DC, Yang Y, Wakabayashi Y, Adelstein RS, Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation. J Cell Sci. 2017 Aug 15;130(16):2696-2706
1	J:308031 Ma X, Uchida Y, Wei T, Liu C, Adams RH, Kubota Y, Gutkind JS, Mukouyama YS, Adelstein RS, Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis. Mol Biol Cell. 2020 Aug 15;31(18):1974-1987
5	J:125412 Maddala R, Skiba N, Vasantha Rao P, Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. Differentiation. 2007 Oct;75(8):713-25
1	J:148322 Marcos S, Moreau J, Backer S, Job D, Andrieux A, Bloch-Gallego E, Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone. PLoS One. 2009;4(4):e5405
6	J:90712 Marigo V, Nigro A, Pecci A, Montanaro D, Di Stazio M, Balduini CL, Savoia A, Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains. Genomics. 2004 Jun;83(6):1125-33
1	J:219576 McGreevy EM, Vijayraghavan D, Davidson LA, Hildebrand JD, Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biol Open. 2015;4(2):186-96
4*	J:18718 Mieziewska K, Szel A, Van Veen T, Aguirre GD, Philp N, Redistribution of insoluble interphotoreceptor matrix components during photoreceptor differentiation in the mouse retina. J Comp Neurol. 1994 Jul 1;345(1):115-24
2	J:231604 Muccioli M, Qaisi D, Herman K, Plageman TF Jr, Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition. Dev Biol. 2016 Apr 1;412(1):32-43
1*	J:281311 Nakano Y, Wiechert S, Banfi B, Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8
2	J:185597 Ohmura T, Shioi G, Hirano M, Aizawa S, Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012 Aug;241(8):1350-64
1*	J:175443 Plageman TF Jr, Zacharias AL, Gage PJ, Lang RA, Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. Dev Biol. 2011 Sep 1;357(1):227-34
3	J:187967 Plosa EJ, Gooding KA, Zent R, Prince LS, Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov;241(11):1770-81
1	J:343286 Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ, Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
4	J:238551 Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV, Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol. 2016 Dec;18(12):1281-1291
2	J:244798 Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R, Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 2015 May;26(5):1081-91
5	J:248868 Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE, Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct;13(10):e1007068
10*	J:308323 Schliffka MF, Tortorelli AF, Ozguc O, de Plater L, Polzer O, Pelzer D, Maitre JL, Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development. Elife. 2021 Apr 19;10:e68536
1	J:154782 Strilic B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E, The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell. 2009 Oct;17(4):505-15
1*	J:275336 Sulistomo HW, Nemoto T, Yanagita T, Takeya R, Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction. J Biol Chem. 2019 Feb 22;294(8):2924-2934
1	J:218919 Sumigray K, Zhou K, Lechler T, Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS One. 2014;9(7):e101824
3*	J:308237 Sun J, Qiao YN, Tao T, Zhao W, Wei LS, Li YQ, Wang W, Wang Y, Zhou YW, Zheng YY, Chen X, Pan HC, Zhang XN, Zhu MS, Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Front Physiol. 2020;11:593966
1	J:222460 Tenin G, Clowes C, Wolton K, Krejci E, Wright JA, Lovell SC, Sedmera D, Hentges KE, Erbb2 is required for cardiac atrial electrical activity during development. PLoS One. 2014;9(9):e107041
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6*	J:51992 Tsuda T, Majumder K, Linask KK, Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stages. Dev Genet. 1998;23(3):203-14
4*	J:44181 Tullio AN, Accili D, Ferrans VJ, Yu ZX, Takeda K, Grinberg A , Westphal H , Preston YA , Adelstein RS, Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12407-12
4	J:68664 Tullio AN, Bridgman PC, Tresser NJ, Chan CC, Conti MA, Adelstein RS, Hara Y, Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J Comp Neurol. 2001 Apr 23;433(1):62-74
2	J:160285 Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R, Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9240-5
2*	J:60967 Uren D, Hwang HK, Hara Y, Takeda K, Kawamoto S, Tullio AN, Yu ZX, Ferrans VJ, Tresser N, Grinberg A, Preston YA, Adelstein RS, Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice. J Clin Invest. 2000 Mar;105(5):663-71
3	J:163702 Wang A, Ma X, Conti MA, Liu C, Kawamoto S, Adelstein RS, Nonmuscle myosin II isoform and domain specificity during early mouse development. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50
1	J:152174 Weimer JM, Yokota Y, Stanco A, Stumpo DJ, Blackshear PJ, Anton ES, MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex. Development. 2009 Sep;136(17):2965-75
1	J:250140 Wilson NR, Olm-Shipman AJ, Acevedo DS, Palaniyandi K, Hall EG, Kosa E, Stumpff KM, Smith GJ, Pitstick L, Liao EC, Bjork BC, Czirok A, Saadi I, SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep. 2016 Jan 20;6:17735
1	J:278242 Xia M, Luo W, Jin H, Yang Z, HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13):dev177477
3*	J:305110 Xu X, Vogel BE, A secreted protein promotes cleavage furrow maturation during cytokinesis. Curr Biol. 2011 Jan 25;21(2):114-9
13	J:149532 Yamamoto N, Okano T, Ma X, Adelstein RS, Kelley MW, Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development. 2009 Jun;136(12):1977-86
1	J:158149 Yen WW, Williams M, Periasamy A, Conaway M, Burdsal C, Keller R, Lu X, Sutherland A, PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation. Development. 2009 Jun;136(12):2039-48
1	J:168852 Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M, KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011 Mar 15;20(6):1061-73
1	J:317371 Zhang Y, Liu C, Adelstein RS, Ma X, Replacing nonmuscle myosin 2A with myosin 2C1 permits gastrulation but not placenta vascular development in mice. Mol Biol Cell. 2018 Sep 15;29(19):2326-2335