Gene Expression Literature Summary

• Symbol: Elp1
• Name: elongator complex protein 1
• ID: MGI:1914544

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E3	E7	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)										1		2		1	1		1									1
In situ RNA (section)													1	1		1	1						1	1
Immunohistochemistry (whole mount)																										1
In situ reporter (knock in)						1	1	1		1		3							1			2				1
Northern blot					1						1							1								1
Western blot																	1			1	1	2				5
RT-PCR	1	1	1	1			2		1	1									1		1	1		1	1	3
cDNA clones																										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Elp1  elongator complex protein 1   (Synonyms: 3110040G09Rik, C78473, IKAP, Ikbkap)
Results	Reference
1	J:312438 Cameron B, Lehrmann E, Chih T, Walters J, Buksch R, Snyder S, Goffena J, Lefcort F, Becker KG, George L, Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway. Biol Open. 2021 Sep 15;10(9):bio058979
5	J:241784 Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson GA, Lefcort F, The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system. Dis Model Mech. 2017 May 01;10(5):605-618
3	J:145561 Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, Slaugenhaupt SA, Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol. 2009 Feb;29(3):736-44
8*	J:150477 Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L, Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell. 2009 Feb 6;136(3):551-64
5*	J:72647 Cuajungco MP, Leyne M, Mull J, Gill SP, Gusella JF, Slaugenhaupt SA, Cloning, characterization, and genomic structure of the mouse Ikbkap gene. DNA Cell Biol. 2001 Sep;20(9):579-86
2	J:188923 Dietrich P, Alli S, Shanmugasundaram R, Dragatsis I, IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia. Hum Mol Genet. 2012 Dec 1;21(23):5078-90
3	J:178070 Dietrich P, Yue J, E S, Dragatsis I, Deletion of exon 20 of the familial dysautonomia gene ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality. PLoS One. 2011;6(10):e27015
1	J:312377 Even A, Morelli G, Turchetto S, Shilian M, Bail RL, Laguesse S, Krusy N, Brisker A, Brandis A, Inbar S, Chariot A, Saudou F, Dietrich P, Dragatsis I, Brone B, Broix L, Rigo JM, Weil M, Nguyen L, ATP-citrate lyase promotes axonal transport across species. Nat Commun. 2021 Oct 7;12(1):5878
1	J:280869 Freeman S, Mateo Sanchez S, Pouyo R, Van Lerberghe PB, Hanon K, Thelen N, Thiry M, Morelli G, Van Hees L, Laguesse S, Chariot A, Nguyen L, Delacroix L, Malgrange B, Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Rep. 2019 Sep;20(9):e47097
5	J:202989 George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F, Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18698-703
1	J:306113 Kojic M, Gawda T, Gaik M, Begg A, Salerno-Kochan A, Kurniawan ND, Jones A, Drozdzyk K, Koscielniak A, Chramiec-Glabik A, Hediyeh-Zadeh S, Kasherman M, Shim WJ, Sinniah E, Genovesi LA, Abrahamsen RK, Fenger CD, Madsen CG, Cohen JS, Fatemi A, Stark Z, Lunke S, Lee J, Hansen JK, Boxill MF, Keren B, Marey I, Saenz MS, Brown K, Alexander SA, Mureev S, Batzilla A, Davis MJ, Piper M, Boden M, Burne THJ, Palpant NJ, Moller RS, Glatt S, Wainwright BJ, Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nat Commun. 2021 May 11;12(1):2678
1*	J:273516 Laguesse S, Close P, Van Hees L, Chariot A, Malgrange B, Nguyen L, Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Front Cell Neurosci. 2017;11:122
4	J:326569 Leonard CE, Quiros J, Lefcort F, Taneyhill LA, Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia. Elife. 2022 Jun 17;11:e71455
6	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
2	J:237480 Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G, Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. PLoS Genet. 2016 Dec;12(12):e1006486
1	J:301847 Ni L, Xie H, Tan L, Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Mol Reprod Dev. 2016 Dec;83(12):1060-1069
1	J:325765 Tolman Z, Chaverra M, George L, Lefcort F, Elp1 is required for development of visceral sensory peripheral and central circuitry. Dis Model Mech. 2022 May 1;15(5):dmm049274
6*	J:287112 Yang KT, Inoue A, Lee YJ, Jiang CL, Lin FJ, Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility. Sci Rep. 2019 Dec 11;9(1):18875