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Gene Expression Literature Summary
Symbol
Name
ID
Lgr4
leucine-rich repeat-containing G protein-coupled receptor 4
MGI:1891468

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E7.5 E8.5 E10.5 E11 E11.5 E12.5 E13.5 E14.5 E15 E15.5 E16.5 E17 E17.5 E18.5 E19.5 A
In situ protein (section) 1 1
In situ RNA (section) 1 2
In situ RNA (whole mount) 1 1
In situ reporter (knock in) 1 1 1 3 1 1 2 3 1 1 4
Northern blot 1 1 1 1 1
RT-PCR 1 1 2 2 1 1 2 1 5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4   (Synonyms: A330106J01Rik, A930009A08Rik, Gpr48)
Results  Reference
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
3*J:141686 Jin C, Yin F, Lin M, Li H, Wang Z, Weng J, Liu M, Da Dong X, Qu J, Tu L, GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4245-53
1J:126813 Kato S, Mohri Y, Matsuo T, Ogawa E, Umezawa A, Okuyama R, Nishimori K, Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice. FEBS Lett. 2007 Oct 2;581(24):4685-90
1J:67920 Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M, Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 8;410(6825):174-9
5*J:68632 Loh ED, Broussard SR, Kolakowski LF, Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. Biochem Biophys Res Commun. 2001 Apr 6;282(3):757-64
3J:152843 Luo J, Zhou W, Zhou X, Li D, Weng J, Yi Z, Cho SG, Li C, Yi T, Wu X, Li XY, de Crombrugghe B, Hook M, Liu M, Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development. 2009 Aug;136(16):2747-56
3J:92077 Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ, Leucine-rich repeat-containing, g protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol. 2004 Sep;18(9):2241-54
3J:139012 Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K, Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn. 2008 Aug;237(8):2235-42
8J:172277 Mohri Y, Oyama K, Akamatsu A, Kato S, Nishimori K, Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3. Dev Dyn. 2011 Jun;240(6):1626-34
4J:173765 Mustata RC, Van Loy T, Lefort A, Libert F, Strollo S, Vassart G, Garcia MI, Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep. 2011 Jun;12(6):558-64
1J:111998 Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC, The mouse gcd2 mutation causes primordial germ cell depletion. Mech Dev. 2006 Jul;123(7):559-69
3J:133339 Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L, McCaffery P, Wrana JL, Attisano L, Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell. 2008 Mar;14(3):411-23
1J:157895 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
2J:144074 Song H, Luo J, Luo W, Weng J, Wang Z, Li B, Li D, Liu M, Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway. J Biol Chem. 2008 Dec 26;283(52):36687-97
5J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
3J:147036 Yamashita R, Takegawa Y, Sakumoto M, Nakahara M, Kawazu H, Hoshii T, Araki K, Yokouchi Y, Yamamura K, Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Dev Dyn. 2009 Apr;238(4):993-1000

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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory