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Gene Expression Literature Summary
Symbol
Name
ID
Foxc1
forkhead box C1
MGI:1347466

67 matching records from 67 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14.5 E15 E15.5 E16.5 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 5 2 4 2 2 1 1
In situ RNA (section) 1 1 3 2 9 8 2 4 1 8 2 6 7 2 2 4 1 3
In situ protein (whole mount) 1
In situ RNA (whole mount) 1 3 4 2 2 6 4 4 3 1 1
In situ reporter (knock in) 1 3 3 3 2 3 2 1 2 2
Northern blot 1 1 1
Western blot 1
RT-PCR 1 1 1 1 3 3 1 4 1 2 2 4
cDNA clones 2 1
RNase protection 1 1 2 1 1 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Foxc1  forkhead box C1   (Synonyms: fkh1, fkh-1, Fkh1, FREAC3, frkhda, Mf1, Mf4)
Results  Reference
2J:152710 Aldinger KA, Lehmann OJ, Hudgins L, Chizhikov VV, Bassuk AG, Ades LC, Krantz ID, Dobyns WB, Millen KJ, FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009 Sep;41(9):1037-42
3J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
1J:70561 Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG, Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell. 1999 May 28;97(5):587-98
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:71240 Feiner L, Webber AL, Brown CB, Lu MM, Jia L, Feinstein P, Mombaerts P, Epstein JA, Raper JA, Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development. 2001 Aug;128(16):3061-70
1*J:55575 Furumoto TA, Miura N, Akasaka T, Mizutani-Koseki Y, Sudo H, Fukuda K , Maekawa M , Yuasa S , Fu Y , Moriya H , Taniguchi M , Imai K , Dahl E , Balling R , Pavlova M , Gossler A , Koseki H, Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev Biol. 1999 Jun 1;210(1):15-29
2J:136041 Gage PJ, Qian M, Wu D, Rosenberg KI, The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol. 2008 May 1;317(1):310-24
1J:91658 Gitler AD, Lu MM, Epstein JA, PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
1*J:86790 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ, Molecular markers of cardiac endocardial cushion development. Dev Dyn. 2003 Dec;228(4):643-50
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
2*J:47627 Hiemisch H, Monaghan AP, Schutz G, Kaestner KH, Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives. Mech Dev. 1998 Apr;73(1):129-32
5*J:50469 Hiemisch H, Schutz G, Kaestner KH, The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues. Gene. 1998 Oct 5;220(1-2):77-82
1J:138257 Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD, Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb;13(2):159-70
1J:148019 Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC, FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development. 2009 May;136(10):1741-50
2J:134970 Inoue T, Ogawa M, Mikoshiba K, Aruga J, Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008 Apr 30;28(18):4712-25
1J:152572 Iwao K, Inatani M, Matsumoto Y, Ogata-Iwao M, Takihara Y, Irie F, Yamaguchi Y, Okinami S, Tanihara H, Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest. 2009 Jul;119(7):1997-2008
3J:175792 Jelcick AS, Yuan Y, Leehy BD, Cox LC, Silveira AC, Qiu F, Schenk S, Sachs AJ, Morrison MA, Nystuen AM, DeAngelis MM, Haider NB, Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One. 2011;6(7):e21858
9*J:14165 Kaestner KH, Lee KH, Schlondorff J, Hiemisch H, Monaghan AP, Schutz G, Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7628-31
9*J:56425 Kidson SH, Kume T, Deng K, Winfrey V, Hogan BL, The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol. 1999 Jul 15;211(2):306-22
2J:79898 Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA, The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1;251(1):157-66
4J:213620 Kong P, Racedo SE, Macchiarulo S, Hu Z, Carpenter C, Guo T, Wang T, Zheng D, Morrow BE, Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
4*J:60834 Kume T, Deng K, Hogan BL, Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development. 2000 Apr;127(7):1387-95
6*J:48079 Kume T, Deng KY, Winfrey V, Gould DB, Walter MA, Hogan BL, The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell. 1998 Jun 12;93(6):985-96
4J:71693 Kume T, Jiang H, Topczewska JM, Hogan BL, The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82
1J:147576 Kunisada M, Cui CY, Piao Y, Ko MS, Schlessinger D, Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet. 2009 May 15;18(10):1769-78
1J:203791 Kuracha MR, Siefker E, Licht JD, Govindarajan V, Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
2J:156014 Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME, Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009 Dec;17(6):892-9
2J:173635 Lieven O, Ruther U, The Dkk1 dose is critical for eye development. Dev Biol. 2011 Jul 1;355(1):124-37
1J:102847 Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB, Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 2005 Nov;132(21):4789-800
8J:105944 Mattiske D, Kume T, Hogan BL, The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol. 2006 Feb 15;290(2):447-58
4J:107208 Mattiske D, Sommer P, Kidson SH, Hogan BL, The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. Dev Dyn. 2006 Apr;235(4):1074-80
1J:206883 Murashima A, Akita H, Okazawa M, Kishigami S, Nakagata N, Nishinakamura R, Yamada G, Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm. Dev Biol. 2014 Feb 1;386(1):216-26
2J:185279 Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S, Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. Hum Mol Genet. 2012 Jul 15;21(14):3143-55
2J:60307 Pressman CL, Chen H, Johnson RL, LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye. Genesis. 2000 Jan;26(1):15-25
2J:185652 Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X, Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 2012 Aug;139(15):2730-9
4J:85739 Rice R, Rice DP, Olsen BR, Thesleff I, Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003 Oct 1;262(1):75-87
11*J:11921 Sasaki H, Hogan BL, Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
1J:188816 Sasman A, Nassano-Miller C, Shim KS, Koo HY, Liu T, Schultz KM, Millay M, Nanano A, Kang M, Suzuki T, Kume T, Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis. 2012 Oct;50(10):766-74
3J:131426 Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H, Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
1J:148989 Schmidt K, Hughes C, Chudek JA, Goodyear SR, Aspden RM, Talbot R, Gundersen TE, Blomhoff R, Henderson C, Wolf CR, Tickle C, Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol. 2009 May;29(10):2716-29
2J:119144 Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T, The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006 Jun 15;294(2):458-70
5J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
1J:181974 Seo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T, Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
2J:157301 Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ, Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009 Oct 30;139(3):597-609
2J:199438 Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ, Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15;2(7):647-59
2J:194058 Sun J, Ishii M, Ting MC, Maxson R, Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44
2*J:34243 Sutton J, Costa R, Klug M, Field L, Xu D, Largaespada DA, Fletcher CF, Jenkins NA, Copeland NG, Klemsz M, Hromas R, Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells. J Biol Chem. 1996 Sep 20;271(38):23126-33
5J:57295 Swiderski RE, Reiter RS, Nishimura DY, Alward WL, Kalenak JW, Searby CS, Stone EM, Sheffield VC, Lin JJ, Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Dev Dyn. 1999 Sep;216(1):16-27
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1J:168146 Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L, Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011 Feb 1;25(3):238-50
1J:213975 Tian H, Sanders E, Reynolds A, van Roy F, van Hengel J, Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells. Invest Ophthalmol Vis Sci. 2012 Aug;53(9):5139-53
3J:128012 Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB, Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development. 2007 Oct;134(20):3723-32
4J:184831 Uchibe K, Shimizu H, Yokoyama S, Kuboki T, Asahara H, Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
3J:137357 Vivatbutsiri P, Ichinose S, Hytonen M, Sainio K, Eto K, Iseki S, Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J Anat. 2008 May;212(5):603-11
3J:188772 Voss AK, Vanyai HK, Collin C, Dixon MP, McLennan TJ, Sheikh BN, Scambler P, Thomas T, MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
1J:93182 Wang B, Weidenfeld J, Lu MM, Maika S, Kuziel WA, Morrisey EE, Tucker PW, Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development. 2004 Sep;131(18):4477-87
3J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
2J:213512 Werber M, Wittler L, Timmermann B, Grote P, Herrmann BG, The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
1J:39636 Winnier GE, Hargett L, Hogan BL, The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 1997 Apr 1;11(7):926-40
8*J:57677 Winnier GE, Kume T, Deng K, Rogers R, Bundy J, Raines C, Walter MA, Hogan BL, Conway SJ, Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999 Sep 15;213(2):418-31
1J:81296 Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D, Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev. 2003 Jan 15;17(2):269-81
3*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2*J:39344 Yoshikawa Y, Fujimori T, McMahon AP, Takada S, Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol. 1997 Mar 15;183(2):234-42
2J:166528 Zacharias AL, Gage PJ, Canonical Wnt/beta-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn. 2010 Dec;239(12):3215-25
3J:136459 Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ, Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14002-7
1J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76

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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory