Gene Expression Literature Summary

• Symbol: Sema3e
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
• ID: MGI:1340034

50 matching records from 50 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)										1				1		1
In situ RNA (section)	1	1	1	1	1	2	1	10	1	7		13	2	9	1	12	1	4	1	2	3	4	10
In situ RNA (whole mount)	1	1	1	1	1			4		1		1				1
In situ reporter (knock in)																							2
Northern blot						2		1		2		1		2		1		2			1		2
Western blot												1											1
RT-PCR						1		3		1	1	3		1		1			1	1		1	4
cDNA clones																						1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sema3e  sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E   (Synonyms: mKIAA0331, Semah)
Results	Reference
1	J:131380 Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD, Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008 Jan 16;28(3):622-32
1	J:160610 Bellon A, Luchino J, Haigh K, Rougon G, Haigh J, Chauvet S, Mann F, VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain. Neuron. 2010 Apr 29;66(2):205-19
4	J:316485 Bribian A, Nocentini S, Llorens F, Gil V, Mire E, Reginensi D, Yoshida Y, Mann F, del Rio JA, Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex. Nat Commun. 2014 Jun 27;5:4265
1	J:244667 Burk K, Mire E, Bellon A, Hocine M, Guillot J, Moraes F, Yoshida Y, Simons M, Chauvet S, Mann F, Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Nat Commun. 2017 Feb 22;8:14508
1	J:222928 Cariboni A, Andre V, Chauvet S, Cassatella D, Davidson K, Caramello A, Fantin A, Bouloux P, Mann F, Ruhrberg C, Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. J Clin Invest. 2015 Jun;125(6):2413-28
3	J:132724 Chauvet S, Cohen S, Yoshida Y, Fekrane L, Livet J, Gayet O, Segu L, Buhot MC, Jessell TM, Henderson CE, Mann F, Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron. 2007 Dec 6;56(5):807-22
3	J:49908 Chedotal A, Del Rio JA, Ruiz M, He Z, Borrell V, de Castro F, Ezan F, Goodman CS, Tessier-Lavigne M, Sotelo C, Soriano E, Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 1998 Nov;125(21):4313-23
4	J:103829 Chen B, Schaevitz LR, McConnell SK, Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9
14	J:46372 Christensen CR, Klingelhofer J, Tarabykina S, Hulgaard EF, Kramerov D, Lukanidin E, Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 1998 Mar 15;58(6):1238-44
4	J:124081 Chung L, Yang TL, Huang HR, Hsu SM, Cheng HJ, Huang PH, Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development. 2007 Aug;134(16):2935-45
2*	J:100439 Cohen S, Funkelstein L, Livet J, Rougon G, Henderson CE, Castellani V, Mann F, A semaphorin code defines subpopulations of spinal motor neurons during mouse development. Eur J Neurosci. 2005 Apr;21(7):1767-76
1	J:340939 Deacon E, Li A, Boivin F, Dvorkin-Gheva A, Cunanan J, Bridgewater D, beta-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development. Dev Dyn. 2023 Sep;252(9):1224-1239
1	J:197849 Deck M, Lokmane L, Chauvet S, Mailhes C, Keita M, Niquille M, Yoshida M, Yoshida Y, Lebrand C, Mann F, Grove EA, Garel S, Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 6;77(3):472-84
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:111207 Dionne MS, Brunet LJ, Eimon PM, Harland RM, Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol. 2002 Nov 15;251(2):283-93
1	J:201994 Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K, The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4026-35
2	J:174966 Erskine L, Reijntjes S, Pratt T, Denti L, Schwarz Q, Vieira JM, Alakakone B, Shewan D, Ruhrberg C, VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron. 2011 Jun 9;70(5):951-65
2*	J:255607 Fu X, Xu J, Chaturvedi P, Liu H, Jiang R, Lan Y, Identification of Osr2 Transcriptional Target Genes in Palate Development. J Dent Res. 2017 Nov;96(12):1451-1458
2	J:205528 Fukuhara K, Imai F, Ladle DR, Katayama K, Leslie JR, Arber S, Jessell TM, Yoshida Y, Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling. Cell Rep. 2013 Nov 14;5(3):748-58
3	J:95697 Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD, Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
1	J:263230 Helmbacher F, Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis. PLoS Biol. 2018 May;16(5):e2004734
1*	J:85300 Helmbacher F, Dessaud E, Arber S, deLapeyriere O, Henderson CE, Klein R, Maina F, Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools. Neuron. 2003 Aug 28;39(5):767-77
4*	J:230339 Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JB, Hofstra RM, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A, Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet. 2015 Apr 2;96(4):581-96
2	J:239871 Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I, Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15;142(22):3954-63
1	J:205955 Katayama K, Imai F, Suto F, Yoshida Y, Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. PLoS One. 2013;8(8):e72512
1	J:153883 Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ, Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J Neurosci. 2009 Oct 7;29(40):12542-57
1	J:174591 Lamballe F, Genestine M, Caruso N, Arce V, Richelme S, Helmbacher F, Maina F, Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. 2011 Aug 3;31(31):11144-58
2	J:255020 Lee H, Kim M, Kim N, Macfarlan T, Pfaff SL, Mastick GS, Song MR, Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. Exp Neurol. 2015 Jul;269:17-27
5	J:91290 Lillesaar C, Fried K, Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage. Neuroscience. 2004;125(1):149-61
2	J:330969 Martins LF, Brambilla I, Motta A, de Pretis S, Bhat GP, Badaloni A, Malpighi C, Amin ND, Imai F, Almeida RD, Yoshida Y, Pfaff SL, Bonanomi D, Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. Neuron. 2022 Oct 7;
5	J:306872 Maruyama K, Naemura K, Arima Y, Uchijima Y, Nagao H, Yoshihara K, Singh MK, Uemura A, Matsuzaki F, Yoshida Y, Kurihara Y, Miyagawa-Tomita S, Kurihara H, Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. iScience. 2021 Apr 23;24(4):102305
3	J:260018 Mata A, Gil V, Perez-Clausell J, Dasilva M, Gonzalez-Calixto MC, Soriano E, Garcia-Verdugo JM, Sanchez-Vives MV, Del Rio JA, New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation. Sci Rep. 2018 Jan 22;8(1):1381
12	J:192712 Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O, Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
4*	J:56207 Miyazaki N, Furuyama T, Amasaki M, Sugimoto H, Sakai T, Takeda N, Kubo T, Inagaki S, Mouse semaphorin H inhibits neurite outgrowth from sensory neurons. Neurosci Res. 1999 Apr;33(4):269-74
10	J:56478 Miyazaki N, Furuyama T, Sakai T, Fujioka S, Mori T, Ohoka Y, Takeda N, Kubo T, Inagaki S, Developmental localization of semaphorin H messenger RNA acting as a collapsing factor on sensory axons in the mouse brain. Neuroscience. 1999;93(1):401-8
1	J:226687 Morello F, Prasad AA, Rehberg K, Vieira de Sa R, Anton-Bolanos N, Leyva-Diaz E, Adolfs Y, Tissir F, Lopez-Bendito G, Pasterkamp RJ, Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development. J Neurosci. 2015 Oct 21;35(42):14205-19
5	J:207212 Oh WJ, Gu C, Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013 Oct 16;80(2):458-69
3	J:80875 Oster SF, Bodeker MO, He F, Sretavan DW, Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development. 2003 Feb;130(4):775-84
1	J:325108 Paganoni AJJ, Amoruso F, Porta Pelayo J, Calleja-Perez B, Vezzoli V, Duminuco P, Caramello A, Oleari R, Fernandez-Jaen A, Cariboni A, A Novel Loss-of-Function SEMA3E Mutation in a Patient with Severe Intellectual Disability and Cognitive Regression. Int J Mol Sci. 2022 May 18;23(10)
2	J:225736 Payne S, Burney MJ, McCue K, Popal N, Davidson SM, Anderson RH, Scambler PJ, A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015 Sep 1;405(1):82-95
3	J:149553 Pecho-Vrieseling E, Sigrist M, Yoshida Y, Jessell TM, Arber S, Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature. 2009 Jun 11;459(7248):842-6
1	J:174965 Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PC, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P, VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 2011 Jun 9;70(5):966-78
2	J:309382 Sandireddy R, Cibi DM, Gupta P, Singh A, Tee N, Uemura A, Epstein JA, Singh MK, Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. JCI Insight. 2019 Aug 22;4(16)
1*	J:277791 Sar Shalom H, Goldner R, Golan-Vaishenker Y, Yaron A, Balance between BDNF and Semaphorins gates the innervation of the mammary gland. Elife. 2019 Jan 10;8:e41162
1*	J:136315 Takahashi K, Ishida M, Hirokawa K, Takahashi H, Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus. Dev Dyn. 2008 Jun;237(6):1699-708
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3	J:332242 Vieira JR, Shah B, Dupraz S, Paredes I, Himmels P, Schermann G, Adler H, Motta A, Gartner L, Navarro-Aragall A, Ioannou E, Dyukova E, Bonnavion R, Fischer A, Bonanomi D, Bradke F, Ruhrberg C, Ruiz de Almodovar C, Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development. Neuron. 2022 Dec 21;110(24):4074-4089.e6
2	J:255944 Wang Q, Marcucci F, Cerullo I, Mason C, Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm. eNeuro. 2016 Nov-Dec;3(6):ENEURO.0169-16.2016
4*	J:138310 Xu C, Fan CM, Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. Gene Expr Patterns. 2008 Sep;8(7-8):502-7
1	J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88