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Gene Expression Literature Summary
Symbol
Name
ID
Myh4
myosin, heavy polypeptide 4, skeletal muscle
MGI:1339713

34 matching records from 34 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E10.5 E11.5 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E P
Immunohistochemistry (section) 1 1 1 1 1 1 2 11
In situ RNA (section) 1 2 1 1 1 1 1 1 1
Northern blot 1 1 1 1
Western blot 1 1 1 1 1 1 1 1 3
RT-PCR 1 1 2 1 1 1 1 5 1 14
RNase protection 1 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Myh4  myosin, heavy polypeptide 4, skeletal muscle   (Synonyms: MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-IIb, Myhsf)
Results  Reference
1J:178848 An CI, Dong Y, Hagiwara N, Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol. 2011;11:59
1*J:181685 Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC, IKKalpha and alternative NF-kappaB regulate PGC-1beta to promote oxidative muscle metabolism. J Cell Biol. 2012 Feb 20;196(4):497-511
1J:206594 Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS, A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:227271 Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS, Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
4*J:100572 Hagiwara N, Ma B, Ly A, Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev Dyn. 2005 Oct;234(2):301-11
1J:108465 Issa LL, Palmer SJ, Guven KL, Santucci N, Hodgson VR, Popovic K, Joya JE, Hardeman EC, MusTRD can regulate postnatal fiber-specific expression. Dev Biol. 2006 May 1;293(1):104-15
2J:224980 Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR, Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054
1J:201148 Lee YS, Lee SJ, Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
11J:58904 Lu BD, Allen DL, Leinwand LA, Lyons GE, Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. Dev Biol. 1999 Dec 1;216(1):312-26
4J:2569 Lucas M, Goblet C, Keller A, Lamande N, Gros F, Whalen RG, Lazar M, Modulation of embryonic and muscle-specific enolase gene products in the developing mouse hindlimb. Differentiation. 1992 Sep;51(1):1-7
1J:31856 Lyons GE, Ontell M, Cox R, Sassoon D, Buckingham M, The expression of myosin genes in developing skeletal muscle in the mouse embryo. J Cell Biol. 1990 Oct;111(4):1465-76
13J:125838 Merrick D, Ting T, Stadler LK, Smith J, A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre. BMC Dev Biol. 2007;7:65
4J:100019 Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, van Rooij E, Richardson JA, Hill JA, De Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA, Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol. 2005 Aug;25(15):6629-38
4*J:16215 Ontell MP, Sopper MM, Lyons G, Buckingham M, Ontell M, Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity. Dev Dyn. 1993 Nov;198(3):203-13
1J:162164 Otto A, Macharia R, Matsakas A, Valasek P, Mankoo BS, Patel K, A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity. Dev Biol. 2010 Jul 1;343(1-2):51-62
1J:69803 Palmer S, Groves N, Schindeler A, Yeoh T, Biben C, Wang CC, Sparrow DB, Barnett L, Jenkins NA, Copeland NG, Koentgen F, Mohun T, Harvey RP, The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner. J Cell Biol. 2001 May 28;153(5):985-98
1J:212185 Petchey LK, Risebro CA, Vieira JM, Roberts T, Bryson JB, Greensmith L, Lythgoe MF, Riley PR, Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20
1J:156173 Plageman TF Jr, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA, Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development. 2010 Feb;137(3):405-15
2J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
1*J:159505 Rossi AC, Mammucari C, Argentini C, Reggiani C, Schiaffino S, Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. J Physiol. 2010 Jan 15;588(Pt 2):353-64
3J:226889 Sakakibara I, Santolini M, Ferry A, Hakim V, Maire P, Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet. 2014;10(5):e1004386
1*J:83690 Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G, Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. J Mol Biol. 2003 Feb 7;326(1):137-49
1J:239493 Sigoillot SM, Bourgeois F, Karmouch J, Molgo J, Dobbertin A, Chevalier C, Houlgatte R, Leger J, Legay C, Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency. FASEB J. 2016 Jun;30(6):2382-99
1*J:203329 Siles L, Sanchez-Tillo E, Lim JW, Darling DS, Kroll KL, Postigo A, ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. Mol Cell Biol. 2013 Apr;33(7):1368-82
2J:32187 Smith TH, Miller JB, Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro. Dev Biol. 1992 Jan;149(1):16-26
1J:230727 Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JP, Vallee J, Robitaille R, Garcia ML, Cornelison DD, Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91
4*J:85709 Usami A, Abe S, Ide Y, Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development. Anat Histol Embryol. 2003 Aug;32(4):244-8
1J:155756 van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN, A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009 Nov;17(5):662-73
1J:54065 Vivian JL, Gan L, Olson EN, Klein WH, A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 1;208(1):44-55
1J:228946 Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, Chen L, Xie Z, Lu Y, Feng Y, SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57
3*J:8621 Weydert A, Barton P, Harris AJ, Pinset C, Buckingham M, Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro. Cell. 1987 Apr 10;49(1):121-9
2J:26105 Zhang W, Behringer RR, Olson EN, Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99
1*J:228546 Zhou H, Wan B, Grubisic I, Kaplan T, Tjian R, TAF7L modulates brown adipose tissue formation. Elife. 2014;3

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory