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Gene Expression Literature Summary
Symbol
Name
ID
Men1
multiple endocrine neoplasia 1
MGI:1316736

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E8.5 E9.5 E10.5 E11 E11.5 E12.5 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18.5 E P
Immunohistochemistry (section) 1 2 2 1 1 1 1 2 1 9
In situ RNA (section) 1 2 2 3
In situ RNA (whole mount) 1 1 3 3 1
Northern blot 3 3 1 3 3 4
Western blot 2 1 1 1 4
RT-PCR 1 3
cDNA clones 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Men1  multiple endocrine neoplasia 1   (Synonyms: menin)
Results  Reference
11*J:52338 Bassett JH, Rashbass P, Harding B, Forbes SA, Pannett AA, Thakker RV, Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1. J Bone Miner Res. 1999 Jan;14(1):3-10
2*J:83882 Bertolino P, Radovanovic I, Casse H, Aguzzi A, Wang ZQ, Zhang CX, Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev. 2003 May;120(5):549-60
1J:228228 Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX, Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83
6J:127545 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA, Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol. 2007 Nov 15;311(2):524-37
6J:141158 Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX, Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol. 2008 Nov;199(2):287-98
5J:95102 Forsberg L, Zablewska B, Piehl F, Weber G, Lagercrantz S, Gaudray P, Hoog C, Larsson C, Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse. Int J Mol Med. 2001 Dec;8(6):681-9
9*J:55083 Guru SC, Crabtree JS, Brown KD, Dunn KJ, Manickam P, Prasad NB , Wangsa D , Burns AL , Spiegel AM , Marx SJ , Pavan WJ , Collins FS , Chandrasekharappa SC, Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. Mamm Genome. 1999 Jun;10(6):592-6
1J:131455 Lemmens IH, Forsberg L, Pannett AA, Meyen E, Piehl F, Turner JJ, Van de Ven WJ, Thakker RV, Larsson C, Kas K, Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun. 2001 Aug 17;286(2):426-31
1J:236960 Lemos MC, Harding B, Reed AA, Jeyabalan J, Walls GV, Bowl MR, Sharpe J, Wedden S, Moss JE, Ross A, Davidson D, Thakker RV, Genetic background influences embryonic lethality and the occurrence of neural tube defects in Men1 null mice: relevance to genetic modifiers. J Endocrinol. 2009 Oct;203(1):133-42
2J:234890 Li F, Su Y, Cheng Y, Jiang X, Peng Y, Li Y, Lu J, Gu Y, Zhang C, Cao Y, Wang W, Ning G, Conditional deletion of Men1 in the pancreatic beta-cell leads to glucagon-expressing tumor development. Endocrinology. 2015 Jan;156(1):48-57
3J:186115 Lu J, Hamze Z, Bonnavion R, Herath N, Pouponnot C, Assade F, Fontaniere S, Bertolino P, Cordier-Bussat M, Zhang CX, Reexpression of oncoprotein MafB in proliferative beta-cells and Men1 insulinomas in mouse. Oncogene. 2012 Aug 2;31(31):3647-54
3J:236958 Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX, Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010 May;138(5):1954-65
2J:239946 Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV, Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing beta-cells to a delta-like fate and reveals a facultative proliferative capacity in aged beta-cells. Development. 2015 Nov 01;142(21):3637-48
1J:107099 Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK, Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol. 2006 Feb;4(2):e39
11*J:51201 Stewart C, Parente F, Piehl F, Farnebo F, Quincey D, Silins G , Bergman L , Carle GF , Lemmens I , Grimmond S , Xian CZ , Khodei S , Teh BT , Lagercrantz J , Siggers P , Calender A , Van de Vem V , Kas K , Weber G , Hayward N , Gaudray P , Larsson C, Characterization of the mouse Men1 gene and its expression during development. Oncogene. 1998 Nov 12;17(19):2485-93
2J:192496 Xu S, Wu H, Wang X, Shen X, Guo X, Shen R, Wang F, Tumor suppressor menin mediates peripheral nerve injury-induced neuropathic pain through potentiating synaptic plasticity. Neuroscience. 2012 Oct 25;223:473-85
1J:183048 Yokoyama A, Ficara F, Murphy MJ, Meisel C, Naresh A, Kitabayashi I, Cleary ML, Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci. 2011 Jul 1;124(Pt 13):2208-19
2*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48

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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory