Gene Expression Literature Summary

• Symbol: Alcam
• Name: activated leukocyte cell adhesion molecule
• ID: MGI:1313266

62 matching records from 62 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			1	3	5		10	3	8	4	12	1	3		4	1	1		4		3		1		7
In situ RNA (section)			1		1	1	4	2	5	2	4	1	6	1	7	1	5	1	3	1	1	1	3	1	4
Immunohistochemistry (whole mount)	1	1	2		1	1		2		1		1
In situ RNA (whole mount)	1	2	2	2	1	1	1						1		1		1
In situ reporter (knock in)								1		1															1
Northern blot																									1
Western blot											1		1		1		1				1	1			1
RT-PCR							3				2		1		2				2				1		3
cDNA clones													1				1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Alcam  activated leukocyte cell adhesion molecule   (Synonyms: BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1)
Results	Reference
7	J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977
3	J:182736 Bravo-Ambrosio A, Mastick G, Kaprielian Z, Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling. Development. 2012 Apr;139(8):1435-46
1	J:220736 Bye CR, Jonsson ME, Bjorklund A, Parish CL, Thompson LH, Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
7	J:279156 Bye CR, Rytova V, Alsanie WF, Parish CL, Thompson LH, Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins. J Neurosci. 2019 Aug 21;39(34):6656-6667
1*	J:119269 Caqueret A, Boucher F, Michaud JL, Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
1	J:284139 Chaimowicz C, Ruffault PL, Cheret C, Woehler A, Zampieri N, Fortin G, Garratt AN, Birchmeier C, Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. Development. 2019 Sep 6;146(17):dev174045
1*	J:214968 Cho G, Lim Y, Cho IT, Simonet JC, Golden JA, Arx together with FoxA2, regulates Shh floor plate expression. Dev Biol. 2014 Sep 1;393(1):137-48
1	J:166533 Daneman R, Zhou L, Kebede AA, Barres BA, Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010 Nov 25;468(7323):562-6
4	J:308786 Delgado C, Bu L, Zhang J, Liu FY, Sall J, Liang FX, Furley AJ, Fishman GI, Neural cell adhesion molecule is required for ventricular conduction system development. Development. 2021 Jun 1;148(11):dev199431
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
11	J:102358 Dillon AK, Fujita SC, Matise MP, Jarjour AA, Kennedy TE, Kollmus H, Arnold HH, Weiner JA, Sanes JR, Kaprielian Z, Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord. J Neurosci. 2005 Nov 2;25(44):10119-30
7	J:123211 Dillon AK, Jevince AR, Hinck L, Ackerman SL, Lu X, Tessier-Lavigne M, Kaprielian Z, UNC5C is required for spinal accessory motor neuron development. Mol Cell Neurosci. 2007 Jul;35(3):482-9
2	J:249067 Dominici C, Moreno-Bravo JA, Puiggros SR, Rappeneau Q, Rama N, Vieugue P, Bernet A, Mehlen P, Chedotal A, Floor-plate-derived netrin-1 is dispensable for commissural axon guidance. Nature. 2017 May 18;545(7654):350-354
2	J:253971 Dominici C, Rappeneau Q, Zelina P, Fouquet S, Chedotal A, Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins. Development. 2018 Jan 17;145(2):dev150375
1	J:262472 Edmond M, Hanley O, Philippidou P, Topoisomerase IIbeta Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0404-17.2017
1	J:306456 Farini D, Cesari E, Weatheritt RJ, La Sala G, Naro C, Pagliarini V, Bonvissuto D, Medici V, Guerra M, Di Pietro C, Rizzo FR, Musella A, Carola V, Centonze D, Blencowe BJ, Marazziti D, Sette C, A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Cell Rep. 2020 Jun 2;31(9):107703
4*	J:92176 Ficker M, Powles N, Warr N, Pirvola U, Maconochie M, Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
10*	J:84355 Fraboulet S, Kavvadia K, Pourquie O, Sharpe PT, Mitsiadis TA, BEN/DM-GRASP/SC1 expression during mouse facial development: differential expression and regulation in molars and incisors. Gene Expr Patterns. 2003 Jun;3(3):255-9
8*	J:63767 Fraboulet S, Schmidt-Petri T, Dhouailly D, Pourquie O, Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia. Mech Dev. 2000 Jul;95(1-2):221-4
5*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
3*	J:331142 Han P, She Y, Yang Z, Zhuang M, Wang Q, Luo X, Yin C, Zhu J, Jaffrey SR, Ji SJ, Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS Biol. 2022 Nov;20(11):e3001853
2	J:279006 Hasten E, Morrow BE, Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome. PLoS Genet. 2019 Aug;15(8):e1008301
1	J:227404 Hernandez-Enriquez B, Wu Z, Martinez E, Olsen O, Kaprielian Z, Maness PF, Yoshida Y, Tessier-Lavigne M, Tran TS, Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing. Genes Dev. 2015 Dec 15;29(24):2617-32
9*	J:121922 Hirata H, Murakami Y, Miyamoto Y, Tosaka M, Inoue K, Nagahashi A, Jakt LM, Asahara T, Iwata H, Sawa Y, Kawamata S, ALCAM (CD166) is a surface marker for early murine cardiomyocytes. Cells Tissues Organs. 2006;184(3-4):172-80
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:119301 Kadison SR, Murakami F, Matise MP, Kaprielian Z, The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord. Dev Biol. 2006 Aug 15;296(2):499-513
2*	J:89673 Kawauchi D, Kobayashi H, Sekine-Aizawa Y, Fujita SC, Murakami F, MuSC is involved in regulating axonal fasciculation of mouse primary vestibular afferents. Eur J Neurosci. 2003 Oct;18(8):2244-52
4	J:308430 Lopez-Gonzalez L, Alonso A, Garcia-Calero E, de Puelles E, Puelles L, Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling. Front Cell Dev Biol. 2021;9:676121
3*	J:114661 Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF, Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol. 2006 Nov;26(21):7929-41
1	J:311909 Machado CB, Kanning KC, Kreis P, Stevenson D, Crossley M, Nowak M, Iacovino M, Kyba M, Chambers D, Blanc E, Lieberam I, Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development. 2014 Feb;141(4):784-94
1	J:103815 Masino AM, Gallardo TD, Wilcox CA, Olson EN, Williams RS, Garry DJ, Transcriptional regulation of cardiac progenitor cell populations. Circ Res. 2004 Aug 20;95(4):389-97
1	J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:272917 Moreno-Bravo JA, Roig Puiggros S, Mehlen P, Chedotal A, Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance. Neuron. 2019 Feb 20;101(4):625-634.e3
2*	J:127470 Murakami Y, Hirata H, Miyamoto Y, Nagahashi A, Sawa Y, Jakt M, Asahara T, Kawamata S, Isolation of cardiac cells from E8.5 yolk sac by ALCAM (CD166) expression. Mech Dev. 2007 Nov-Dec;124(11-12):830-9
6	J:263065 Ogawa T, Li Y, Lua I, Hartner A, Asahina K, Isolation of a unique hepatic stellate cell population expressing integrin alpha8 from embryonic mouse livers. Dev Dyn. 2018 Jun;247(6):867-881
1	J:161574 Onitsuka I, Tanaka M, Miyajima A, Characterization and functional analyses of hepatic mesothelial cells in mouse liver development. Gastroenterology. 2010 Apr;138(4):1525-35, 1535.e1-6
4	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
1	J:258494 Poissonnier L, Villain G, Soncin F, Mattot V, miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leucocyte adhesion and transmigration. Cardiovasc Res. 2014 Jun 1;102(3):436-47
1	J:171448 Probst S, Kraemer C, Demougin P, Sheth R, Martin GR, Shiratori H, Hamada H, Iber D, Zeller R, Zuniga A, SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011 May;138(10):1913-23
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
2	J:158918 Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chedotal A, Genetic dissection of the function of hindbrain axonal commissures. PLoS Biol. 2010;8(3):e1000325
2	J:213397 Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A, Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells. Circ Res. 2013 Aug 2;113(4):389-98
14	J:50282 Sekine-Aizawa Y, Omori A, Fujita SC, MuSC, a novel member of the immunoglobulin superfamily, is expressed in neurons of a subset of cranial sensory ganglia in the mouse embryo. Eur J Neurosci. 1998 Sep;10(9):2810-24
1*	J:338194 Sulic AM, Das Roy R, Papagno V, Lan Q, Saikkonen R, Jernvall J, Thesleff I, Mikkola ML, Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643
3	J:92208 Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M, Nishinakamura R, Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 2004 Jun;121(6):547-57
4*	J:143778 Tamplin OJ, Cox BJ, Rossant J, Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol. 2011 Dec 15;360(2):415-25
1	J:286533 Tenney AP, Livet J, Belton T, Prochazkova M, Pearson EM, Whitman MC, Kulkarni AB, Engle EC, Henderson CE, Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 Oct 8;29(2):437-452.e4
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:290264 Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P, Phrenic-specific transcriptional programs shape respiratory motor output. Elife. 2020 Jan 16;9:e52859
1	J:277451 Valente M, Resende TP, Nascimento DS, Burlen-Defranoux O, Soares-da-Silva F, Dupont B, Cumano A, Pinto-do-O P, Mouse HSA+ immature cardiomyocytes persist in the adult heart and expand after ischemic injury. PLoS Biol. 2019 Jun;17(6):e3000335
1*	J:284147 Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M, Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B, Reina M, Soriano FX, Hastie ND, Martinez FO, Martinez-Estrada OM, Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development. 2019 Oct 17;146(20):dev178723
2	J:107735 Wang X, Weiner JA, Levi S, Craig AM, Bradley A, Sanes JR, Gamma protocadherins are required for survival of spinal interneurons. Neuron. 2002 Dec 5;36(5):843-54
6	J:93205 Weiner JA, Koo SJ, Nicolas S, Fraboulet S, Pfaff SL, Pourquie O, Sanes JR, Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
1*	J:307862 Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O, Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. Elife. 2021 May 18;10:e60108
2	J:111725 Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L, UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nat Neurosci. 2006 Aug;9(8):996-8
1	J:330827 Yoo D, Park J, Lee C, Song I, Lee YH, Yun T, Lee H, Heguy A, Han JY, Dasen JS, Kim H, Baek M, Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345
2*	J:314891 Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H, Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23;287(13):10355-10367