Gene Expression Literature Summary

• Symbol: Phlda2
• Name: pleckstrin homology like domain, family A, member 2
• ID: MGI:1202307

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E5.5	E6.5	E7	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)						1			1	1		2	1	1		1			1	4
In situ RNA (section)			2	1	1	1	2	1	2	3	1	2		1						2
In situ RNA (whole mount)			1	1	1		2	3	1			1	3	1
Northern blot											2	2		3		1		1	1	5
Western blot											1							1		1
RT-PCR	1	1						1	9	6	2	5	7	4	5		1	2	2	17
cDNA clones						1	1	1
RNase protection															2					2
Primer Extension															1	1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Phlda2  pleckstrin homology like domain, family A, member 2   (Synonyms: Ipl, Tssc3)
Results	Reference
2	J:10529 Bastian H, Gruss P, A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
3	J:266304 Bogutz AB, Oh-McGinnis R, Jacob KJ, Ho-Lau R, Gu T, Gertsenstein M, Nagy A, Lefebvre L, Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage. PLoS Genet. 2018 Aug;14(8):e1007587
1	J:73452 Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH, Dnmt3L and the establishment of maternal genomic imprints. Science. 2001 Dec 21;294(5551):2536-9
2*	J:96366 Cerrato F, Sparago A, Di Matteo I, Zou X, Dean W, Sasaki H, Smith P, Genesio R, Bruggemann M, Reik W, Riccio A, The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet. 2005 Feb 15;14(4):503-11
2*	J:126006 Clark L, Wei M, Cattoretti G, Mendelsohn C, Tycko B, The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. BMC Genet. 2002 Jun 27;3:11
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
1*	J:56342 Dao D, Walsh CP, Yuan L, Gorelov D, Feng L, Hensle T, Nisen P, Yamashiro DJ, Bestor TH, Tycko B, Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum Mol Genet. 1999 Jul;8(7):1337-52
14*	J:80724 Dunwoodie SL, Beddington RS, The expression of the imprinted gene lpl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development. Int J Dev Biol. 2002;46(4):459-66
3	J:121765 Duselis AR, Vrana PB, Assessment and disease comparisons of hybrid developmental defects. Hum Mol Genet. 2007 Apr 1;16(7):808-19
5	J:79882 Fitzpatrick GV, Soloway PD, Higgins MJ, Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002 Nov;32(3):426-31
2	J:76871 Frank D, Fortino W, Clark L, Musalo R, Wang W, Saxena A, Li CM, Reik W, Ludwig T, Tycko B, Placental overgrowth in mice lacking the imprinted gene Ipl. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7490-5
15*	J:58692 Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B, A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999 Dec;10(12):1150-9
1*	J:118209 Green K, Lewis A, Dawson C, Dean W, Reinhart B, Chaillet JR, Reik W, A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA. Mamm Genome. 2007 Jan;18(1):32-42
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:236493 Guo J, He H, Liu H, Liu Q, Zhang L, Liu B, Sugimoto K, Wu Q, Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse. Biol Reprod. 2016 Aug;95(2):40
6*	J:192195 Himes KP, Koppes E, Chaillet JR, Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
6*	J:125749 Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, Hoodless PA, A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol. 2007;7:92
1	J:293051 Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y, Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development. Sci Rep. 2020 Feb 5;10(1):1884
1	J:114401 Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W, Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov;133(21):4203-10
2	J:94246 Lewis A, Mitsuya K, Umlauf D, Smith P, Dean W, Walter J, Higgins M, Feil R, Reik W, Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet. 2004 Dec;36(12):1291-5
1	J:82790 Mager J, Montgomery ND, de Villena FP, Magnuson T, Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
3	J:108700 Mancini-Dinardo D, Steele SJ, Levorse JM, Ingram RS, Tilghman SM, Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
2	J:306136 Manti M, Pui HP, Edstrom S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E, Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. FASEB J. 2020 Nov;34(11):14440-14457
3	J:163857 Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C, Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 Aug 1;137(15):2493-9
4	J:219786 Naillat F, Yan W, Karjalainen R, Liakhovitskaia A, Samoylenko A, Xu Q, Sun Z, Shen B, Medvinsky A, Quaggin S, Vainio SJ, Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Exp Cell Res. 2015 Mar 15;332(2):163-78
1	J:112969 Ogawa H, Wu Q, Komiyama J, Obata Y, Kono T, Disruption of parental-specific expression of imprinted genes in uniparental fetuses. FEBS Lett. 2006 Oct 2;580(22):5377-84
4	J:161410 Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L, Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50
7	J:170637 Oh-McGinnis R, Bogutz AB, Lefebvre L, Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction. Dev Biol. 2011 Mar 15;351(2):277-86
2*	J:148026 Price KL, Woolf AS, Long DA, Unraveling the genetic landscape of bladder development in mice. J Urol. 2009 May;181(5):2366-74
2	J:138143 Rampon C, Bouillot S, Climescu-Haulica A, Prandini MH, Cand F, Vandenbrouck Y, Huber P, Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta. Physiol Genomics. 2008 Jul 15;34(2):193-204
1	J:144190 Redrup L, Branco MR, Perdeaux ER, Krueger C, Lewis A, Santos F, Nagano T, Cobb BS, Fraser P, Reik W, The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development. 2009 Feb;136(4):525-30
1*	J:170412 Rolland AD, Lehmann KP, Johnson KJ, Gaido KW, Koopman P, Uncovering gene regulatory networks during mouse fetal germ cell development. Biol Reprod. 2011 Apr;84(4):790-800
2*	J:325355 Rong Y, Zhu YZ, Yu JL, Wu YW, Ji SY, Zhou Y, Jiang Y, Jin J, Fan HY, Shen L, Sha QQ, USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. Nucleic Acids Res. 2022 Jun 10;50(10):5599-5616
6	J:93878 Salas M, John R, Saxena A, Barton S, Frank D, Fitzpatrick G, Higgins MJ, Tycko B, Placental growth retardation due to loss of imprinting of Phlda2. Mech Dev. 2004 Oct;121(10):1199-210
2	J:268910 Segura-Bayona S, Knobel PA, Gonzalez-Buron H, Youssef SA, Pena-Blanco A, Coyaud E, Lopez-Rovira T, Rein K, Palenzuela L, Colombelli J, Forrow S, Raught B, Groth A, de Bruin A, Stracker TH, Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell Death Differ. 2017 Nov;24(11):1872-1885
1	J:275000 Sharma A, Lacko LA, Argueta LB, Glendinning MD, Stuhlmann H, miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Dev Biol. 2019 May 1;449(1):21-34
1	J:240089 Sharma N, Kubaczka C, Kaiser S, Nettersheim D, Mughal SS, Riesenberg S, Holzel M, Winterhager E, Schorle H, Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Development. 2016 Mar 01;143(5):787-98
2	J:130529 Shin JY, Fitzpatrick GV, Higgins MJ, Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J. 2008 Jan 9;27(1):168-78
2	J:274138 Singh VB, Sribenja S, Wilson KE, Attwood KM, Hillman JC, Pathak S, Higgins MJ, Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Development. 2017 May 15;144(10):1820-1830
1*	J:161404 Stevens J, Ermakov A, Braganca J, Hilton H, Underhill P, Bhattacharya S, Brown NA, Norris DP, Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. BMC Dev Biol. 2010;10:54
4	J:236398 Tunster SJ, McNamara GI, Creeth HD, John RM, Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Dev Biol. 2016 Oct 1;418(1):55-65
7	J:156412 Tunster SJ, Tycko B, John RM, The imprinted Phlda2 gene regulates extraembryonic energy stores. Mol Cell Biol. 2010 Jan;30(1):295-306
2*	J:177542 Tunster SJ, Van de Pette M, John RM, Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Dis Model Mech. 2011 Nov;4(6):814-21
3*	J:130398 Wagschal A, Sutherland HG, Woodfine K, Henckel A, Chebli K, Schulz R, Oakey RJ, Bickmore WA, Feil R, G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol Cell Biol. 2008 Feb;28(3):1104-13
2*	J:161712 Zaitoun I, Downs KM, Rosa GJ, Khatib H, Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting. Epigenetics. 2010 Feb;5(2):149-58