Gene Expression Literature Summary

• Symbol: Chek1
• Name: checkpoint kinase 1
• ID: MGI:1202065

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E3	E7.5	E8.5	E9	E10	E10.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)		1				1					1		3	3		2	1				1
In situ RNA (whole mount)										1			1	1
Northern blot														1							1
Western blot		1		1	1	1		1		2				2					1		3
RT-PCR	1	1	1	1	1		1	1	1		3	1	1	1	1		1	1		1	7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Chek1  checkpoint kinase 1   (Synonyms: Chk1)
Results	Reference
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
3*	J:170314 Albino D, Brizzolara A, Moretti S, Falugi C, Mirisola V, Scaruffi P, Di Candia M, Truini M, Coco S, Bonassi S, Tonini GP, Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration. Int J Dev Biol. 2011;55(1):65-72
2*	J:187030 Chen CH, Chu PC, Lee L, Lien HW, Lin TL, Fan CC, Chi P, Huang CJ, Chang MS, Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response. PLoS One. 2012;7(3):e33538
6	J:262653 D'Ignazio L, Michel M, Beyer M, Thompson K, Forabosco A, Schlessinger D, Pelosi E, Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage. Biol Reprod. 2018 Apr 1;98(4):532-542
1	J:297431 Dewhurst MR, Ow JR, Zafer G, van Hul NKM, Wollmann H, Bisteau X, Brough D, Choi H, Kaldis P, Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020 Nov;16(11):e1009084
1	J:309209 Dhomen N, Da Rocha Dias S, Hayward R, Ogilvie L, Hedley D, Delmas V, McCarthy A, Henderson D, Springer CJ, Pritchard C, Larue L, Marais R, Inducible expression of (V600E) Braf using tyrosinase-driven Cre recombinase results in embryonic lethality. Pigment Cell Melanoma Res. 2010 Feb;23(1):112-20
1	J:233087 Dong D, Yu J, Wu Y, Fu N, Villela NA, Yang P, Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem Biophys Res Commun. 2015 Nov 13;467(2):407-12
1	J:325537 Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB, Sun QY, PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development. Development. 2022 May 15;149(10):dev200351
1*	J:309183 Gomes AL, Matos-Rodrigues GE, Frappart PO, Martins RAP, RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Front Cell Dev Biol. 2020;8:711
1*	J:149642 Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C, The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod. 2009 May;80(5):944-53
5*	J:121524 Hasthorpe S, Tainton K, Peart M, Roeszler KN, Bell KM, Lusby PE, Hutson JM, Tymms MJ, G2/M checkpoint gene expression in developing germ cells. Mol Reprod Dev. 2007 May;74(5):531-8
1	J:252381 Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T, The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017 Jun;35(6):1614-1623
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1	J:191367 Lee Y, Katyal S, Downing SM, Zhao J, Russell HR, McKinnon PJ, Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci. 2012 Jun;15(6):819-26
1	J:181920 Lee Y, Shull ER, Frappart PO, Katyal S, Enriquez-Rios V, Zhao J, Russell HR, Brown EJ, McKinnon PJ, ATR maintains select progenitors during nervous system development. EMBO J. 2012 Mar 7;31(5):1177-89
3*	J:316150 Li R, Yang YG, Gao Y, Wang ZQ, Tong WM, A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res. 2012 May;22(5):859-72
2	J:185038 Martinez P, Flores JM, Blasco MA, 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. J Cell Biol. 2012 Apr 16;197(2):283-300
2	J:184928 Miles DC, van den Bergen JA, Wakeling SI, Anderson RB, Sinclair AH, Western PS, The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol. 2012 May 1;365(1):101-9
2	J:183999 Ouseph MM, Li J, Chen HZ, Pecot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G, Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
5	J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1	J:223048 Pirouz M, Pilarski S, Kessel M, A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013 Aug;9(8):e1003712
2*	J:42767 Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H , Elledge SJ, Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 [see comments]. Science. 1997 Sep 5;277(5331):1497-501
2*	J:272586 Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4):dev168146
1	J:315979 Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, Satoh Y, Kusakabe A, Ogawa S, Kanai A, Molkentin JD, Nakamura K, Ohbayashi T, Takeuchi T, Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J Biol Chem. 2014 Jun 27;289(26):18033-44
1	J:314615 Xu C, Shen WB, Reece EA, Hasuwa H, Harman C, Kaushal S, Yang P, Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin. Sci Adv. 2021 Jun;7(27)
1*	J:239876 Xu Q, Wang F, Xiang Y, Zhang X, Zhao ZA, Gao Z, Liu W, Lu X, Liu Y, Yu XJ, Wang H, Huang J, Yi Z, Gao S, Li L, Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 2015 Nov 15;142(22):3943-53
2*	J:92323 Zeng F, Baldwin DA, Schultz RM, Transcript profiling during preimplantation mouse development. Dev Biol. 2004 Aug 15;272(2):483-96
1	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247
2	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147