Gene Expression Literature Summary

• Symbol: Dscam
• Name: DS cell adhesion molecule
• ID: MGI:1196281

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)						1		1			1					1					1
In situ RNA (section)			1	1		2		4		6	2		7		3	4	1	1	3		1	5
In situ RNA (whole mount)		1		1	1	1			1			1									1	1
In situ reporter (knock in)																1
Northern blot	1						1							1			1					1
Western blot								2		1	1				1	1		1	1			3
RT-PCR			1	1						1			1		2				1	1		3
cDNA clones																						2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dscam  DS cell adhesion molecule   (Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule)
Results	Reference
12*	J:67853 Agarwala KL, Ganesh S, Amano K, Suzuki T, Yamakawa K, Dscam, a highly conserved gene in mammals, expressed in differentiating mouse brain. Biochem Biophys Res Commun. 2001 Mar 2;281(3):697-705
7	J:313612 Arimura N, Okada M, Taya S, Dewa KI, Tsuzuki A, Uetake H, Miyashita S, Hashizume K, Shimaoka K, Egusa S, Nishioka T, Yanagawa Y, Yamakawa K, Inoue YU, Inoue T, Kaibuchi K, Hoshino M, DSCAM regulates delamination of neurons in the developing midbrain. Sci Adv. 2020 Sep;6(36)
1*	J:80442 Barlow GM, Lyons GE, Richardson JA, Sarnat HB, Korenberg JR, DSCAM: an endogenous promoter drives expression in the developing CNS and neural crest. Biochem Biophys Res Commun. 2002 Nov 22;299(1):1-6
8*	J:76619 Barlow GM, Micales B, Chen XN, Lyons GE, Korenberg JR, Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?. Biochem Biophys Res Commun. 2002 May 10;293(3):881-91
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
3	J:297714 Brignani S, Raj DDA, Schmidt ERE, Dudukcu O, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chedotal A, Pasterkamp RJ, Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. 2020 Aug 19;107(4):684-702.e9
4	J:240943 Bruce FM, Brown S, Smith JN, Fuerst PG, Erskine L, DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1702-1707
5	J:320476 Chen P, Liu Z, Zhang Q, Lin D, Song L, Liu J, Jiao HF, Lai X, Zou S, Wang S, Zhou T, Li BM, Zhu L, Pan BX, Fei E, DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. J Neurosci. 2022 Jan 26;42(4):532-551
2	J:126582 Cobos I, Borello U, Rubenstein JL, Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007 Jun 21;54(6):873-88
4	J:155397 Fuerst PG, Bruce F, Tian M, Wei W, Elstrott J, Feller MB, Erskine L, Singer JH, Burgess RW, DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Neuron. 2009 Nov 25;64(4):484-97
3*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
1*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
3	J:159129 Liu G, Li W, Wang L, Kar A, Guan KL, Rao Y, Wu JY, DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2951-6
1*	J:143806 Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E, DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell. 2008 Jun 27;133(7):1241-54
4	J:192581 Maynard KR, Stein E, DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex. J Neurosci. 2012 Nov 21;32(47):16637-50
3	J:304361 Mitsogiannis MD, Pancho A, Aerts T, Sachse SM, Vanlaer R, Noterdaeme L, Schmucker D, Seuntjens E, Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration. Front Cell Dev Biol. 2020;8:624181
1	J:188355 Miyoshi G, Fishell G, Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron. 2012 Jun 21;74(6):1045-58
1	J:179910 Palmesino E, Haddick PC, Tessier-Lavigne M, Kania A, Genetic Analysis of DSCAM's Role as a Netrin-1 Receptor in Vertebrates. J Neurosci. 2012 Jan 11;32(2):411-6
1	J:250766 Poliak S, Morales D, Croteau LP, Krawchuk D, Palmesino E, Morton S, Cloutier JF, Charron F, Dalva MB, Ackerman SL, Kao TJ, Kania A, Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife. 2015 Dec 3;4:e10841
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
10*	J:45496 Yamakawat K, Huot YK, Haendelt MA, Hubert R, Chen XN, Lyons GE, Korenberg JR, DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet. 1998 Feb;7(2):227-37
1*	J:74198 Zhao Z, Yaar R, Ladd D, Cataldo LM, Ravid K, Overexpression of a3 adenosine receptors in smooth, cardiac, and skeletal muscle is lethal to embryos. Microvasc Res. 2002 Jan;63(1):61-9