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Gene Expression Literature Summary
Symbol
Name
ID
Sftpa1
surfactant associated protein A1
MGI:109518

110 matching records from 110 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E3.5 E9.5 E11 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E P
Immunohistochemistry (section) 1 2 2 1 1 1 4 2 2 2 8 2 1 3 8
In situ RNA (section) 3 1 2 1 4
Northern blot 2 2 1 3 3 1 4 2 6
Western blot 1 1 1 4 9 1 1 7
RT-PCR 1 1 1 3 1 2 5 1 2 6 1 14 4 46 1 2 1 2 17
cDNA clones 1
RNase protection 1 2 1
Nuclease S1 1 1 1 2 1
Primer Extension 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Sftpa1  surfactant associated protein A1   (Synonyms: Sftp1, Sftp-1, SFTPA1, SP-A, surfactant pulmonary associated protein A1)
Results  Reference
1J:223051 Albert M, Schmitz SU, Kooistra SM, Malatesta M, Morales Torres C, Rekling JC, Johansen JV, Abarrategui I, Helin K, The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet. 2013 Apr;9(4):e1003461
2J:45341 Aubin J, Lemieux M, Tremblay M, Berard J, Jeannotte L, Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects. Dev Biol. 1997 Dec 15;192(2):432-45
2*J:38383 Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL, Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 1997 Jan;124(1):53-63
5J:173973 Benlhabib H, Mendelson CR, Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol Cell Biol. 2011 May;31(10):1949-58
2J:180979 Besnard V, Wert SE, Ikegami M, Xu Y, Heffner C, Murray SA, Donahue LR, Whitsett JA, Maternal synchronization of gestational length and lung maturation. PLoS One. 2011;6(11):e26682
4J:104973 Besnard V, Wert SE, Kaestner KH, Whitsett JA, Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1. Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L750-9
1*J:171712 Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, Hooper SB, Cole TJ, cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
1*J:60658 Bouwman P, Gollner H, Elsasser HP, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G, Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000 Feb 15;19(4):655-61
1*J:221769 Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M, Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57
1*J:39016 Cardoso WV, Itoh A, Nogawa H, Mason I, Brody JS, FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium. Dev Dyn. 1997 Mar;208(3):398-405
1J:339854 Chen SY, Liu FC, The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung. Development. 2023 Aug 15;150(16):dev201827
1J:302676 Cheong H, Wu J, Gonzales LK, Guttentag SH, Thompson CB, Lindsten T, Analysis of a lung defect in autophagy-deficient mouse strains. Autophagy. 2014 Jan;10(1):45-56
2J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
1*J:28289 Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, Whitsett JA, Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7794-8
1J:27441 Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
1J:129796 Conkright JJ, Na CL, Weaver TE, Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice. Am J Respir Cell Mol Biol. 2002 Jan;26(1):85-90
2J:276950 Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A, Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep. 2019 May 7;27(6):1769-1780.e4
2*J:85424 DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA, TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003 Sep 12;278(37):35574-83
6J:170236 El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D, Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1;350(1):112-26
7J:173840 El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D, Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15;353(2):242-58
1*J:105164 Fernandez-Valdivia R, Zhang Y, Pai S, Metzker ML, Schumacher A, l7Rn6 Encodes a Novel Protein Required for Clara Cell Function in Mouse Lung Development. Genetics. 2006 Jan;172(1):389-99
2J:250104 Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B, The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49
1J:163382 Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, Bodine P, D'Armiento J, The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol. 2010 Aug;177(2):598-607
2J:204701 Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S, Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013;8(7):e69451
2J:224542 Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR, Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest. 2015 Jul 1;125(7):2808-24
4J:282733 Gerlini R, Amendola E, Conte A, Valente V, Tornincasa M, Credendino SC, Cammarota F, Gentile C, Di Guida L, Paladino S, De Vita G, Fusco A, Pierantoni GM, Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice. Cell Death Dis. 2019 Oct 3;10(10):747
1J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1J:76787 Goshu E, Jin H, Fasnacht R, Sepenski M, Michaud JL, Fan CM, Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol. 2002 Jun;22(12):4147-57
1*J:117591 Grad I, McKee TA, Ludwig SM, Hoyle GW, Ruiz P, Wurst W, Floss T, Miller CA 3rd, Picard D, The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol. 2006 Dec;26(23):8976-83
2*J:75698 Grunder A, Ebel TT, Mallo M, Schwarzkopf G, Shimizu T, Sippel AE, Schrewe H, Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
2*J:136735 Ha HY, Kim JB, Cho IH, Joo HJ, Kim KS, Lee KW, Sunwoo H, Im JY, Lee JK, Hong JH, Han PL, Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins. Proteomics. 2008 Mar;8(5):1071-80
3J:98913 Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ, Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?. Circ Res. 2004 Apr 30;94(8):1115-23
1*J:243650 Herriges MJ, Tischfield DJ, Cui Z, Morley MP, Han Y, Babu A, Li S, Lu M, Cendan I, Garcia BA, Anderson SA, Morrisey EE, The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis. Genes Dev. 2017 May 01;31(9):889-903
1J:173651 Hsu YC, Osinski J, Campbell CE, Litwack ED, Wang D, Liu S, Bachurski CJ, Gronostajski RM, Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation. Dev Biol. 2011 Jun 15;354(2):242-52
2J:150516 Hu Z, Wang C, Xiao Y, Sheng N, Chen Y, Xu Y, Zhang L, Mo W, Jing N, Hu G, NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. J Cell Sci. 2009 Apr 15;122(Pt 8):1145-54
3J:80523 Hundertmark S, Dill A, Ebert A, Zimmermann B, Kotelevtsev YV, Mullins JJ, Seckl JR, Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice. Horm Metab Res. 2002 Oct;34(10):545-9
1J:199909 Im SK, Jeong H, Jeong HW, Kim KT, Hwang D, Ikegami M, Kong YY, Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
1J:306809 Inagaki M, Nishimura T, Nakanishi T, Shimada H, Noguchi S, Akanuma SI, Tachikawa M, Hosoya KI, Tamai I, Nakashima E, Tomi M, Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction. iScience. 2020 May 22;23(5):101098
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1J:213127 Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML, Lymphatic function is required prenatally for lung inflation at birth. J Exp Med. 2014 May 5;211(5):815-26
3J:33469 Jaskoll T, Choy HA, Melnick M, The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo. Pediatr Res. 1996 May;39(5):749-59
3J:265611 Jin J, Li Y, Ren J, Man Lam S, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ, Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016 Mar;54(3):410-23
2J:130907 Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O'Connor CL, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ, A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol. 2008 Jan 1;180(1):601-8
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4J:165381 Liu W, Purevdorj E, Zscheppang K, von Mayersbach D, Behrens J, Brinkhaus MJ, Nielsen HC, Schmiedl A, Dammann CE, ErbB4 regulates the timely progression of late fetal lung development. Biochim Biophys Acta. 2010 Jul;1803(7):832-9
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1J:85946 Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, Birchmeier W, Morrisey EE, Whitsett JA, beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem. 2003 Oct 10;278(41):40231-8
3J:53721 Muglia LJ, Bae DS, Brown TT, Vogt SK, Alvarez JG, Sunday ME, Majzoub JA, Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. Am J Respir Cell Mol Biol. 1999 Feb;20(2):181-8
1J:282576 Nakajima K, Ono M, Radovic U, Dizdarevic S, Tomizawa SI, Kuroha K, Nagamatsu G, Hoshi I, Matsunaga R, Shirakawa T, Kurosawa T, Miyazaki Y, Seki M, Suzuki Y, Koseki H, Nakamura M, Suda T, Ohbo K, Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice. Dis Model Mech. 2019 Nov 12;12(11):dmm040139
1J:161950 O'Brien KB, Alberich-Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S, CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul;137(13):2147-56
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2J:277582 Oeckinghaus A, Postler TS, Rao P, Schmitt H, Schmitt V, Grinberg-Bleyer Y, Kuhn LI, Gruber CW, Lienhard GE, Ghosh S, kappaB-Ras proteins regulate both NF-kappaB-dependent inflammation and Ral-dependent proliferation. Cell Rep. 2014 Sep 25;8(6):1793-1807
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1*J:63996 Ringvall M, Ledin J, Holmborn K, van Kuppevelt T, Ellin F, Eriksson I, Olofsson AM, Kjellen L, Forsberg E, Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1. J Biol Chem. 2000 Aug 25;275(34):25926-30
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1J:332515 Wan L, Hu X, Xia T, Li F, Chi Q, Ma H, Yan S, Li W, Huang W, Disruption of Cdyl gene impairs mouse lung epithelium differentiation and maturation. Gene. 2023 Feb 15;853:147088
1J:211804 Woik N, Dietz CT, Schaker K, Kroll J, Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2alpha in mice. Dis Model Mech. 2014 Jun;7(6):683-92
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6*J:31260 Wuenschell CW, Sunday ME, Singh G, Minoo P, Slavkin HC, Warburton D, Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. J Histochem Cytochem. 1996 Feb;44(2):113-23
2J:157922 Xing Y, Li C, Li A, Sridurongrit S, Tiozzo C, Bellusci S, Borok Z, Kaartinen V, Minoo P, Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar;137(5):825-33
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