Gene Expression Literature Summary

• Symbol: Epha8
• Name: Eph receptor A8
• ID: MGI:109378

33 matching records from 33 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)				1										1
In situ RNA (section)				3	1	4	5	8	6	2		3	5	5
In situ RNA (whole mount)			2	1									1	1
In situ reporter (knock in)			1											1
RT-PCR	1	1				1	1	2	1	2	1		1	6
cDNA clones														1
RNase protection		1	1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Epha8  Eph receptor A8   (Synonyms: Eek, EphA8, Hek3)
Results	Reference
2	J:150093 Abdul-Aziz NM, Turmaine M, Greene ND, Copp AJ, EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. Int J Dev Biol. 2009;53(4):559-68
4*	J:216216 Agrawal P, Wang M, Kim S, Lewis AE, Bush JO, Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Dev Dyn. 2014 Nov;243(11):1470-6
1	J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977
1	J:277122 Buenaventura DF, Corseri A, Emerson MM, Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2787-2799
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:263194 Ebisu H, Iwai-Takekoshi L, Fujita-Jimbo E, Momoi T, Kawasaki H, Foxp2 Regulates Identities and Projection Patterns of Thalamic Nuclei During Development. Cereb Cortex. 2017 Jul 1;27(7):3648-3659
1*	J:116642 Fujii H, Tatsumi K, Kosaka K, Yoshioka S, Fujiwara H, Fujii S, Eph-ephrin A system regulates murine blastocyst attachment and spreading. Dev Dyn. 2006 Dec;235(12):3250-8
1	J:217584 Gerstmann K, Pensold D, Symmank J, Khundadze M, Hubner CA, Bolz J, Zimmer G, Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Development. 2015 Jan 1;142(1):140-50
2	J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
6	J:162837 Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK, Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep;55(9):2478-88
3	J:62323 Jeong J, Choi S, Gu C, Lee H, Park S, Genomic structure and promoter analysis of the mouse EphA8 receptor tyrosine kinase gene. DNA Cell Biol. 2000 May;19(5):291-300
1*	J:82771 Koo J, Shim S, Gu C, Yoo O, Park S, Identification of an enhancer region in the mouse ephA8 locus directing expression to the anterior region of the dorsal mesencephalon. Dev Dyn. 2003 Apr;226(4):596-603
3	J:95080 Luukko K, Loes S, Kvinnsland IH, Kettunen P, Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues. Cell Tissue Res. 2005 Jan;319(1):143-52
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
6	J:41127 Park S, Frisen J, Barbacid M, Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 1997 Jun 2;16(11):3106-14
1	J:38350 Park S, Sanchez MP, The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
1*	J:83513 Pickles JO, Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003 Apr;178(1-2):44-51
1	J:325971 Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N, Regulation of prefrontal patterning and connectivity by retinoic acid. Nature. 2021 Oct;598(7881):483-488
3	J:118901 Shim S, Kim Y, Shin J, Kim J, Park S, Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. Mol Cell Biol. 2007 Mar;27(5):1614-30
4*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1	J:229511 Son AI, Sheleg M, Cooper MA, Sun Y, Kleiman NJ, Zhou R, Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. Invest Ophthalmol Vis Sci. 2014 Mar;55(3):1594-606
1	J:230727 Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JP, Vallee J, Robitaille R, Garcia ML, Cornelison DD, Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91
2*	J:171106 Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T, Dynamic spatiotemporal gene expression in embryonic mouse thalamus. J Comp Neurol. 2011 Feb 15;519(3):528-43
1	J:262201 Teng T, Gaillard A, Muzerelle A, Gaspar P, EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain. eNeuro. 2017 Jan-Feb;4(1):ENEURO.0327-16.2017
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4*	J:105961 van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG, Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006 Apr;6(4):353-9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:279388 Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A, Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463
4*	J:231672 Xavier GM, Miletich I, Cobourne MT, Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60
1*	J:225638 Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A, Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet. 2004 Jul 15;13(14):1487-503
1	J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88
1	J:58437 Yue Y, Su J, Cerretti DP, Fox GM, Jing S, Zhou R, Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. J Neurosci. 1999 Nov 15;19(22):10026-35
3	J:81281 Yun ME, Johnson RR, Antic A, Donoghue MJ, EphA family gene expression in the developing mouse neocortex: Regional patterns reveal intrinsic programs and extrinsic influence. J Comp Neurol. 2003 Feb 10;456(3):203-16