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Gene Expression Literature Summary
Symbol
Name
ID
Efna5
ephrin A5
MGI:107444

76 matching records from 76 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E3.5 E4 E4.5 E5.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 1 1 2 2 3
In situ RNA (section) 1 2 1 3 2 2 10 2 7 4 13 1 6 3 9 1 2 6 7 6 21
In situ RNA (whole mount) 1 5 3 2 2 2 1 1 1 1 1 1
Northern blot 1 1
Western blot 1 1 1 1 1 1
RT-PCR 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 5
cDNA clones 1 1 1
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Efna5  ephrin A5   (Synonyms: AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS)
Results  Reference
3J:150093 Abdul-Aziz NM, Turmaine M, Greene ND, Copp AJ, EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. Int J Dev Biol. 2009;53(4):559-68
1*J:74241 Barbieri AM, Broccoli V, Bovolenta P, Alfano G, Marchitiello A, Mocchetti C, Crippa L, Bulfone A, Marigo V, Ballabio A, Banfi S, Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development. 2002 Feb;129(3):805-13
1J:178526 Bielle F, Marcos-Mondejar P, Leyva-Diaz E, Lokmane L, Mire E, Mailhes C, Keita M, Garcia N, Tessier-Lavigne M, Garel S, Lopez-Bendito G, Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography. Curr Biol. 2011 Oct 25;21(20):1748-55
1J:82130 Bishop KM, Garel S, Nakagawa Y, Rubenstein JL, O'Leary DD, Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J Comp Neurol. 2003 Mar 17;457(4):345-60
1J:78745 Bishop KM, Rubenstein JL, O'Leary DD, Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci. 2002 Sep 1;22(17):7627-38
1J:137136 Blaess S, Stephen D, Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
1J:57538 Broccoli V, Boncinelli E, Wurst W, The caudal limit of Otx2 expression positions the isthmic organizer. Nature. 1999 Sep 9;401(6749):164-8
1J:82216 Bulchand S, Subramanian L, Tole S, Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Dev Dyn. 2003 Mar;226(3):460-9
2J:140400 Campbell TN, Davy A, Liu Y, Arcellana-Panlilio M, Robbins SM, Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1. Biochem Biophys Res Commun. 2008 Oct 24;375(3):362-6
2J:170971 Carreres MI, Escalante A, Murillo B, Chauvin G, Gaspar P, Vegar C, Herrera E, Transcription factor foxd1 is required for the specification of the temporal retina in mammals. J Neurosci. 2011 Apr 13;31(15):5673-81
4J:47983 Castellani V, Yue Y, Gao PP, Zhou R, Bolz J, Dual action of a ligand for Eph receptor tyrosine kinases on specific populations of axons during the development of cortical circuits. J Neurosci. 1998 Jun 15;18(12):4663-72
1J:73073 Chapouton P, Schuurmans C, Guillemot F, Gotz M, The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum. Development. 2001 Dec;128(24):5149-59
1J:147282 Chen L, Guo Q, Li JY, Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development. 2009 Apr;136(8):1317-26
1J:121300 Cholfin JA, Rubenstein JL, Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7652-7
1J:179898 Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW, Otic Mesenchyme Cells Regulate Spiral Ganglion Axon Fasciculation through a Pou3f4/EphA4 Signaling Pathway. Neuron. 2012 Jan 12;73(1):49-63
1*J:73773 de Diego I, Kyriakopoulou K, Karagogeos D, Wassef M, Multiple influences on the migration of precerebellar neurons in the caudal medulla. Development. 2002 Jan;129(2):297-306
4J:99355 Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P, Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature. 2005 Jun 30;435(7046):1244-50
10J:154889 Deschamps C, Faideau M, Jaber M, Gaillard A, Prestoz L, Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway. Exp Neurol. 2009 Oct;219(2):466-80
1J:184356 Dye CA, El Shawa H, Huffman KJ, A lifespan analysis of intraneocortical connections and gene expression in the mouse II. Cereb Cortex. 2011 Jun;21(6):1331-50
5J:184357 Dye CA, El Shawa H, Huffman KJ, A lifespan analysis of intraneocortical connections and gene expression in the mouse I. Cereb Cortex. 2011 Jun;21(6):1311-30
1J:61499 Feldheim DA, Kim YI, Bergemann AD, Frisen J, Barbacid M, Flanagan JG, Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping [see comments]. Neuron. 2000 Mar;25(3):563-74
5J:51889 Feldheim DA, Vanderhaeghen P, Hansen MJ, Frisen J, Lu Q, Barbacid M, Flanagan JG, Topographic guidance labels in a sensory projection to the forebrain. Neuron. 1998 Dec;21(6):1303-13
6J:60774 Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG, Sanes JR, Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. Neuron. 2000 Feb;25(2):295-306
14*J:36483 Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG, Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev Biol. 1996 Nov 1;179(2):382-401
4*J:116642 Fujii H, Tatsumi K, Kosaka K, Yoshioka S, Fujiwara H, Fujii S, Eph-ephrin A system regulates murine blastocyst attachment and spreading. Dev Dyn. 2006 Dec;235(12):3250-8
1J:34329 Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD, Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 1996 Jul;17(1):9-19
2*J:79830 Garel S, Yun K, Grosschedl R, Rubenstein JL, The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development. 2002 Dec;129(24):5621-34
2J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
1J:108511 Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development. 2006 May;133(9):1779-87
2J:81763 Hebert JM, Lin M, Partanen J, Rossant J, McConnell SK, FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development. 2003 Mar;130(6):1101-11
4J:77779 Holmberg J, Clarke DL, Frisen J, Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature. 2000 Nov 9;408(6809):203-6
2J:41861 Hynes M, Stone DM, Dowd M, Pitts-Meek S, Goddard A, Gurney A , Rosenthal A, Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron. 1997 Jul;19(1):15-26
3J:162837 Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK, Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep;55(9):2478-88
1J:144066 Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L, Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23;60(2):258-72
3J:67679 Knoll B, Zarbalis K, Wurst W, Drescher U, A role for the EphA family in the topographic targeting of vomeronasal axons. Development. 2001 Mar;128(6):895-906
1*J:82771 Koo J, Shim S, Gu C, Yoo O, Park S, Identification of an enhancer region in the mouse ephA8 locus directing expression to the anterior region of the dorsal mesencephalon. Dev Dyn. 2003 Apr;226(4):596-603
3J:202990 Lehigh KM, Leonard CE, Baranoski J, Donoghue MJ, Parcellation of the thalamus into distinct nuclei reflects EphA expression and function. Gene Expr Patterns. 2013 Dec;13(8):454-63
1J:79431 Li JY, Lao Z, Joyner AL, Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron. 2002 Sep 26;36(1):31-43
1J:150482 Little GE, Lopez-Bendito G, Runker AE, Garcia N, Pinon MC, Chedotal A, Molnar Z, Mitchell KJ, Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. PLoS Biol. 2009 Apr 28;7(4):e98
1J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
1*J:91057 Louvi A, Sisodia SS, Grove EA, Presenilin 1 in migration and morphogenesis in the central nervous system. Development. 2004 Jul;131(13):3093-105
1J:64091 Louvi A, Wassef M, Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding. Development. 2000 Sep;127(18):4061-71
6J:95080 Luukko K, Loes S, Kvinnsland IH, Kettunen P, Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues. Cell Tissue Res. 2005 Jan;319(1):143-52
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*J:37329 Marcus RC, Gale NW, Morrison ME, Mason CA, Yancopoulos GD, Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina. Dev Biol. 1996 Dec 15;180(2):786-9
3J:87768 Niederkofler V, Salie R, Sigrist M, Arber S, Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci. 2004 Jan 28;24(4):808-18
1*J:156952 North HA, Karim A, Jacquin MF, Donoghue MJ, EphA4 is necessary for spatially selective peripheral somatosensory topography. Dev Dyn. 2010 Feb;239(2):630-8
1J:150346 North HA, Zhao X, Kolk SM, Clifford MA, Ziskind DM, Donoghue MJ, Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009 Jul;136(14):2467-76
1J:112321 Oury F, Murakami Y, Renaud JS, Pasqualetti M, Charnay P, Ren SY, Rijli FM, Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Science. 2006 Sep 8;313(5792):1408-13
1J:38350 Park S, Sanchez MP, The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
4J:138785 Passante L, Gaspard N, Degraeve M, Frisen J, Kullander K, De Maertelaer V, Vanderhaeghen P, Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum. Development. 2008 Oct;135(19):3281-90
1*J:83513 Pickles JO, Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003 Apr;178(1-2):44-51
3J:99629 Rashid T, Upton AL, Blentic A, Ciossek T, Knoll B, Thompson ID, Drescher U, Opposing Gradients of Ephrin-As and EphA7 in the Superior Colliculus Are Essential for Topographic Mapping in the Mammalian Visual System. Neuron. 2005 Jul 7;47(1):57-69
3J:171618 Saeger BM, Suhm M, Neubuser A, Ephrin/ephrin receptor expression during early stages of mouse inner ear development. Dev Dyn. 2011 Jun;240(6):1578-85
1J:154951 Sahara S, O'Leary DD, Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron. 2009 Jul 16;63(1):48-62
1*J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
4J:136752 Sato N, Sugimura Y, Hayashi Y, Murase T, Kanou Y, Kikkawa F, Murata Y, Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction. Endocr J. 2008 May;55(2):317-23
1*J:119722 Shaut CA, Saneyoshi C, Morgan EA, Knosp WM, Sexton DR, Stadler HS, HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia. Dev Dyn. 2007 Feb 15;236(4):951-960
1J:205196 Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S, Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4913-21
1J:92208 Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M, Nishinakamura R, Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 2004 Jun;121(6):547-57
1J:184006 Tang K, Rubenstein JL, Tsai SY, Tsai MJ, COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May;139(9):1630-9
1J:153504 Torii M, Hashimoto-Torii K, Levitt P, Rakic P, Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature. 2009 Sep 24;461(7263):524-8
2J:177159 Torii M, Levitt P, Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism. Neuron. 2005 Nov 23;48(4):563-75
2J:180170 Triplett JW, Pfeiffenberger C, Yamada J, Stafford BK, Sweeney NT, Litke AM, Sher A, Koulakov AA, Feldheim DA, Competition is a driving force in topographic mapping. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19060-5
1J:83004 Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J, FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003 Apr 15;22(8):1811-23
3*J:105961 van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG, Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006 Apr;6(4):353-9
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*J:42110 Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein JL , Martinez S , Martin GR, Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
4J:78359 Yue Y, Chen ZY, Gale NW, Blair-Flynn J, Hu TJ, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, Zhou R, Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10777-82
1J:58437 Yue Y, Su J, Cerretti DP, Fox GM, Jing S, Zhou R, Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. J Neurosci. 1999 Nov 15;19(22):10026-35
4J:144429 Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, Sehara-Fujisawa A, Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS ONE. 2008;3(10):e3322
6J:81281 Yun ME, Johnson RR, Antic A, Donoghue MJ, EphA family gene expression in the developing mouse neocortex: Regional patterns reveal intrinsic programs and extrinsic influence. J Comp Neurol. 2003 Feb 10;456(3):203-16
7*J:62086 Zarbalis K, Wurst W, Expression domains of murine ephrin-A5 in the pituitary and hypothalamus. Mech Dev. 2000 May;93(1-2):165-8
1J:160653 Zembrzycki A, Griesel G, Stoykova A, Mansouri A, Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev. 2007;2:8
2J:139956 Zimmer G, Garcez P, Rudolph J, Niehage R, Weth F, Lent R, Bolz J, Ephrin-A5 acts as a repulsive cue for migrating cortical interneurons. Eur J Neurosci. 2008 Jul;28(1):62-73
2J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory