Gene Expression Literature Summary

• Symbol: Slc16a1
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 1
• ID: MGI:106013

40 matching records from 40 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)								1	4	3	1	6	5	5	1	1	1		1	1	3	5	19
In situ RNA (section)												1	1	5			1				1	1	3
Immunohistochemistry (whole mount)	1	1			1		1		1
Northern blot															1								1
Western blot																							1
RT-PCR	1	2	1	1	1	1	1	1	3			1	3	1	1	2		1		1	2		7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Slc16a1  solute carrier family 16 (monocarboxylic acid transporters), member 1   (Synonyms: MCT1)
Results	Reference
3	J:332870 Andrews S, Krueger C, Mellado-Lopez M, Hemberger M, Dean W, Perez-Garcia V, Hanna CW, Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B. Nat Commun. 2023 Jan 23;14(1):371
3	J:335233 Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A, Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21
2	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:293009 Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S, Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14280-14291
1*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
4	J:171595 Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P, A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21;472(7343):347-50
1	J:332098 Chen X, Tang AT, Tober J, Yang J, Leu NA, Sterling S, Chen M, Yang Y, Mericko-Ishizuka P, Speck NA, Kahn ML, Mouse placenta fetal macrophages arise from endothelial cells outside the placenta. Dev Cell. 2022 Dec 5;57(23):2652-2660.e3
7*	J:88590 Clamp MF, Ochrietor JD, Moroz TP, Linser PJ, Developmental analyses of 5A11/Basigin, 5A11/Basigin-2 and their putative binding partner MCT1 in the mouse eye. Exp Eye Res. 2004 Apr;78(4):777-89
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:219917 Domenech-Estevez E, Baloui H, Repond C, Rosafio K, Medard JJ, Tricaud N, Pellerin L, Chrast R, Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. J Neurosci. 2015 Mar 11;35(10):4151-6
3	J:335574 Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi SH, Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex. Nat Neurosci. 2022 Jul;25(7):865-875
5*	J:76794 Herubel F, El Mouatassim S, Guerin P, Frydman R, Menezo Y, Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002 May;10(2):175-81
2	J:317603 Islam A, Kagawa Y, Sharifi K, Ebrahimi M, Miyazaki H, Yasumoto Y, Kawamura S, Yamamoto Y, Sakaguti S, Sawada T, Tokuda N, Sugino N, Suzuki R, Owada Y, Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA transport in mouse trophoblasts. J Nutr. 2014 Oct;144(10):1509-16
9	J:105942 Jansen S, Esmaeilpour T, Pantaleon M, Kaye PL, Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. Reproduction. 2006 Mar;131(3):469-79
1	J:267504 Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA, Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56
2	J:332500 Kokorudz C, Radford BN, Dean W, Hemberger M, Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain. Cells. 2022 Dec 24;12(1)
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
5	J:323371 Lee JG, Kim G, Park SG, Yon JM, Yeom J, Song HE, Cheong SA, Lim JS, Sung YH, Kim K, Yoo HJ, Hong EJ, Nam KH, Seong JK, Kim CJ, Nam SY, Baek IJ, Lipid signatures reflect the function of the murine primary placentation. Biol Reprod. 2022 Mar 19;106(3):583-596
3	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
2*	J:280426 Matoba S, Nakamuta S, Miura K, Hirose M, Shiura H, Kohda T, Nakamuta N, Ogura A, Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21047-21053
2	J:214760 Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, Dunwoodie SL, Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014 Aug 1;392(1):62-79
1*	J:206636 Nualart F, Castro T, Low M, Henriquez JP, Oyarce K, Cisternas P, Garcia A, Yanez AJ, Bertinat R, Montecinos VP, Garcia-Robles MA, Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development. Histochem Cell Biol. 2013 Feb;139(2):233-47
1	J:286013 Outhwaite JE, Patel J, Simmons DG, Secondary Placental Defects in Cxadr Mutant Mice. Front Physiol. 2019;10:622
3	J:46855 Pellerin L, Pellegri G, Martin JL, Magistretti PJ, Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3990-5
5	J:333799 Radford BN, Zhao X, Glazer T, Eaton M, Blackwell D, Mohammad S, Lo Vercio LD, Devine J, Shalom-Barak T, Hallgrimsson B, Cross JC, Sucov HM, Barak Y, Dean W, Hemberger M, Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Nat Commun. 2023 Mar 1;14(1):1174
1	J:306140 Ren X, Yao LL, Pan JX, Zhang JS, Mei L, Wang YG, Xiong WC, Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy. Neurobiol Dis. 2021 Jul;154:105339
2	J:330449 Rusidze M, Faure MC, Sicard P, Raymond-Letron I, Giton F, Vessieres E, Prevot V, Henrion D, Arnal JF, Cornil CA, Lenfant F, Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683
6	J:320731 Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel A, Lopez-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constancia M, The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8
3	J:262281 Sarkar AA, Sabatino JA, Sugrue KF, Zohn IE, Abnormal labyrinthine zone in the Hectd1-null placenta. Placenta. 2016 Feb;38:16-23
1	J:242899 Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM, Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development. 2017 Jul 01;144(13):2402-2414
2	J:242901 Tai-Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, Kubota Y, Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017 Jul 01;144(13):2392-2401
2	J:345100 Talvi S, Jokinen J, Sipila K, Rappu P, Zhang FP, Poutanen M, Rantakari P, Heino J, Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice. iScience. 2024 Feb 16;27(2):108914
4*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4	J:290416 Vrooman LA, Rhon-Calderon EA, Chao OY, Nguyen DK, Narapareddy L, Dahiya AK, Putt ME, Schultz RM, Bartolomei MS, Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse. Development. 2020 May 29;147(11):dev186551
1	J:306158 Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H, Guo W, Yang X, Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019 Dec 5;25(6):754-767.e9
5	J:235000 Wu HH, Choi S, Levitt P, Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse. Placenta. 2016 Jun;42:74-83
2	J:342367 Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN, Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777
1*	J:326252 Zhang Y, Liang P, Yang L, Shan KZ, Feng L, Chen Y, Liedtke W, Coyne CB, Yang H, Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. Elife. 2022 Jun 7;11:e78840