Gene Expression Literature Summary

• Symbol: Musk
• Name: muscle, skeletal, receptor tyrosine kinase
• ID: MGI:103581

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)									1	2	1	1		1			4	1	3
In situ RNA (section)		1	2	1	2	2	2	1		3		1	1				4		3
Immunohistochemistry (whole mount)										2		1	1		2		2	1	2
In situ RNA (whole mount)										3	1						3		2
Northern blot			1		1		1												2
Western blot										2	1					1	5	1	2
RT-PCR							1			3		1	1		1		4		4
cDNA clones	1		1																1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Musk  muscle, skeletal, receptor tyrosine kinase   (Synonyms: MDK4, Nsk1, Nsk2, Nsk3)
Results	Reference
2	J:161300 An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, Kaspar BK, Ko CP, Lee KF, Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
5	J:111100 Apel ED, Glass DJ, Moscoso LM, Yancopoulos GD, Sanes JR, Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold. Neuron. 1997 Apr;18(4):623-35
11*	J:35622 Besser J, Zahalka MA, Ullrich A, Exclusive expression of the receptor tyrosine kinase MDK4 in skeletal muscle and the decidua. Mech Dev. 1996 Sep;59(1):41-52
4*	J:49489 Bowen DC, Park JS, Bodine S, Stark JL, Valenzuela DM, Stitt TN, Yancopoulos GD, Lindsay RM, Glass DJ, DiStefano PS, Localization and regulation of MuSK at the neuromuscular junction. Dev Biol. 1998 Jul 15;199(2):309-19
3	J:172291 Chen F, Liu Y, Sugiura Y, Allen PD, Gregg RG, Lin W, Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci. 2011 May;14(5):570-7
1	J:126558 Chen F, Qian L, Yang ZH, Huang Y, Ngo ST, Ruan NJ, Wang J, Schneider C, Noakes PG, Ding YQ, Mei L, Luo ZG, Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron. 2007 Jul 19;55(2):247-60
1	J:207796 Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kroger S, Johnson EB, Hammer RE, Lin W, Herz J, APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
1*	J:194894 Couesnon A, Offner N, Bernard V, Chaverot N, Backer S, Dimitrov A, Perez F, Molgo J, Bloch-Gallego E, CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:345130 Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y, Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
8*	J:27415 Ganju P, Walls E, Brennan J, Reith AD, Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis. Oncogene. 1995 Jul 20;11(2):281-90
2*	J:224393 Gartz Hanson M, Niswander LA, Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos. Dev Biol. 2015 Aug 15;404(2):76-87
2	J:80082 Herbst R, Avetisova E, Burden SJ, Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development. 2002 Dec;129(23):5449-60
2	J:126807 Hippenmeyer S, Huber RM, Ladle DR, Murphy K, Arber S, ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles. Neuron. 2007 Sep 6;55(5):726-40
4	J:260261 Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi O, Yamanashi Y, Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation. Sci Signal. 2009 Feb 24;2(59):ra7
1*	J:260151 Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, Konishi H, Masuda A, Imagama S, Kiyama H, Ishiguro N, Ohno K, Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018 Jan 11;8(1):434
2	J:104252 Jaworski A, Burden SJ, Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci. 2006 Jan 11;26(2):655-61
1	J:307970 Jing H, Chen P, Hui T, Yu Z, Zhou J, Fei E, Wang S, Ren D, Lai X, Li B, Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway. Cell Biosci. 2021 Jun 5;11(1):105
1	J:322702 Kaplan MM, Flucher BE, Counteractive and cooperative actions of muscle beta-catenin and CaV1.1 during early neuromuscular synapse formation. iScience. 2022 Apr 15;25(4):104025
3	J:271303 Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE, Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. Cell Rep. 2018 Jun 26;23(13):3891-3904
4	J:129239 Kim N, Burden SJ, MuSK controls where motor axons grow and form synapses. Nat Neurosci. 2008 Jan;11(1):19-27
1	J:316483 Leek CC, Soulas JM, Bhattacharya I, Ganji E, Locke RC, Smith MC, Bhavsar JD, Polson SW, Ornitz DM, Killian ML, Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn. 2021 Dec;250(12):1778-1795
1	J:278545 Li J, Ito M, Ohkawara B, Masuda A, Ohno K, Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction. Sci Rep. 2018 Sep 11;8(1):13577
1	J:60191 Lin W, Sanchez HB, Deerinck T, Morris JK, Ellisman M, Lee KF, Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1299-304
1*	J:149227 Liu Y, Oppenheim RW, Sugiura Y, Lin W, Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev Biol. 2009 Jun 1;330(1):153-66
1	J:134988 Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W, Essential roles of the acetylcholine receptor {gamma}-subunit in neuromuscular synaptic patterning. Development. 2008 Jun;135(11):1957-67
1*	J:134925 Lu Z, Je HS, Young P, Gross J, Lu B, Feng G, Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol. 2007 Jun 18;177(6):1077-89
1	J:221340 Messeant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgo J, Zytnicki D, Schaeffer L, Legay C, Strochlic L, MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance. J Neurosci. 2015 Mar 25;35(12):4926-41
1	J:160510 Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H, Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions. J Neurosci. 2010 May 19;30(20):6954-62
1	J:307372 Ohkawara B, Kobayakawa A, Kanbara S, Hattori T, Kubota S, Ito M, Masuda A, Takigawa M, Lyons KM, Ishiguro N, Ohno K, CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction. EMBO Rep. 2020 Aug 5;21(8):e48462
2	J:136914 Osman AA, Schrader AD, Hawkes AJ, Akil O, Bergeron A, Lustig LR, Simmons DD, Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008 Jun;38(2):153-69
1	J:76364 Pun S, Sigrist M, Santos AF, Ruegg MA, Sanes JR, Jessell TM, Arber S, Caroni P, An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. Neuron. 2002 Apr 25;34(3):357-70
1	J:28731 Reith AD, Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase. Mamm Genome. 1995 Sep;6(9):689
1*	J:70507 Smith CL, Mittaud P, Prescott ED, Fuhrer C, Burden SJ, Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J Neurosci. 2001 May 1;21(9):3151-60
4	J:216752 Tezuka T, Inoue A, Hoshi T, Weatherbee SD, Burgess RW, Ueta R, Yamanashi Y, The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4	J:84331 Wang ZZ, Washabaugh CH, Yao Y, Wang JM, Zhang L, Ontell MP, Watkins SC, Rudnicki MA, Ontell M, Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice. J Neurosci. 2003 Jun 15;23(12):5161-9
4	J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1	J:144429 Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, Sehara-Fujisawa A, Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS One. 2008;3(10):e3322