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Gene Expression Literature Summary
Symbol
Name
ID
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
MGI:103013

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1 E8.5 E9.5 E10.5 E11.5 E12 E12.5 E13 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 A
In situ protein (section) 1 1 1 1 2 2 1 2 3
In situ protein (whole mount) 1
In situ RNA (whole mount) 1
In situ reporter (knock in) 1 1 1
Northern blot 1 1 1 1 1
Western blot 1 1 2 1 1 2 2 3
RT-PCR 1 1 1 1 1 1 1 1 3 1 1 3 7
cDNA clones 1 1
RNase protection 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Cacna1c  calcium channel, voltage-dependent, L type, alpha 1C subunit   (Synonyms: (alpha)1 subunit, Cav1.2, Cchl1a1, D930026N18Rik, L-type Cav1.2)
Results  Reference
7*J:90043 Acosta L, Haase H, Morano I, Moorman AF, Franco D, Regional expression of L-type calcium channel subunits during cardiac development. Dev Dyn. 2004 May;230(1):131-6
1J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
11*J:31819 Chaudhari N, Beam KG, mRNA for cardiac calcium channel is expressed during development of skeletal muscle. Dev Biol. 1993 Feb;155(2):507-15
1*J:86174 Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH, Sox6 regulation of cardiac myocyte development. Nucleic Acids Res. 2003 Oct 15;31(20):5941-8
2*J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
2J:200733 Ding J, Domes K, Hofmann F, Wegener JW, Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes. Pflugers Arch. 2013 Jul;465(7):955-64
2*J:176723 Domes K, Ding J, Lemke T, Blaich A, Wegener JW, Brandmayr J, Moosmang S, Hofmann F, Truncation of murine cav1.2 at asp-1904 results in heart failure after birth. J Biol Chem. 2011 Sep 30;286(39):33863-71
1J:206966 Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE, Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
1*J:37583 Fassler R, Rohwedel J, Maltsev V, Bloch W, Lentini S, Guan K, Gullberg D, Hescheler J, Addicks K, Wobus AM, Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci. 1996 Dec;109(Pt 13):2989-99
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
2*J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
1J:208830 Lin SS, Tzeng BH, Lee KR, Smith RJ, Campbell KP, Chen CC, Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1990-8
7J:156342 Link S, Meissner M, Held B, Beck A, Weissgerber P, Freichel M, Flockerzi V, Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem. 2009 Oct 30;284(44):30129-37
3J:84059 Lu DP, Li Y, Bathgate R, Day M, O'Neill C, Ligand-activated signal transduction in the 2-cell embryo. Biol Reprod. 2003 Jul;69(1):106-16
3J:171157 Marshall MR, Clark JP 3rd, Westenbroek R, Yu FH, Scheuer T, Catterall WA, Functional Roles of a C-terminal Signaling Complex of CaV1 Channels and A-kinase Anchoring Protein 15 in Brain Neurons. J Biol Chem. 2011 Apr 8;286(14):12627-39
1J:186596 Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S, Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011 Aug 19;109(5):512-23
1*J:83693 Porter GA Jr, Makuck RF, Rivkees SA, Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003 Jun;227(2):280-90
2J:197612 Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, Shah RA, Yazawa M, Dolmetsch RE, Kirby ML, Pitt GS, Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. J Clin Invest. 2013 Apr 1;123(4):1638-46
2*J:161494 Schlick B, Flucher BE, Obermair GJ, Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010 May 19;167(3):786-98
4*J:100234 Shao Y, Alicknavitch M, Farach-Carson MC, Expression of voltage sensitive calcium channel (VSCC) L-type Cav1.2 (alpha1C) and T-type Cav3.2 (alpha1H) subunits during mouse bone development. Dev Dyn. 2005 Sep;234(1):54-62
5J:152610 Tang ZZ, Zheng S, Nikolic J, Black DL, Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol. 2009 Sep;29(17):4757-65
3J:101090 Toba Y, Pakiam JG, Wray S, Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse. Eur J Neurosci. 2005 Jul;22(1):79-92
4*J:86180 Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N, Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. J Biol Chem. 2003 Oct 17;278(42):40837-41

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory