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Gene Expression Literature Summary
Symbol
Name
ID
Six1
sine oculis-related homeobox 1
MGI:102780

77 matching records from 77 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14.5 E15 E15.5 E16.5 E17.5 E18.5 E19 E A
In situ protein (section) 1 3 1 5 2 3 1 1 2 1 2 2 3 1 4
In situ RNA (section) 1 2 7 1 17 6 1 5 7 6 4 3 1 3 1 2 4
In situ RNA (whole mount) 2 1 3 2 8 1 13 3 2 2 1 1 1 1
In situ reporter (knock in) 1 2 4 1 6 1 9 2 7 6 7 4 3 1 3 6 2 5
Northern blot 1 1 1 1
Western blot 1 1 2 3 2
RT-PCR 1 1 2 2 1 3 4 4 4 3 2 1 2 4 4
cDNA clones 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Six1  sine oculis-related homeobox 1  
Results  Reference
6J:181471 Ahmed M, Wong EY, Sun J, Xu J, Wang F, Xu PX, Eya1-six1 interaction is sufficient to induce hair cell fate in the cochlea by activating atoh1 expression in cooperation with sox2. Dev Cell. 2012 Feb 14;22(2):377-90
1J:187740 Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM, Borycki AG, Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev. 2012 Sep 15;26(18):2103-17
5*J:98304 Bonnin MA, Laclef C, Blaise R, Eloy-Trinquet S, Relaix F, Maire P, Duprez D, Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation. Mech Dev. 2005 Apr;122(4):573-85
1J:149467 Bosman EA, Quint E, Fuchs H, Hrabe de Angelis M, Steel KP, Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol. 2009 Apr 15;328(2):285-96
10J:145187 Chen B, Kim EH, Xu PX, Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. Dev Biol. 2009 Feb 1;326(1):75-85
2*J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
5J:158421 Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL, Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev Biol. 2010;10:4
2J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1J:206594 Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS, A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
5J:181488 Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG, Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44(3):343-7
1J:131873 Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, Seidman CE, Seidman JG, Eya4-deficient mice are a model for heritable otitis media. J Clin Invest. 2008 Feb;118(2):651-8
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:90613 Dreyer SD, Naruse T, Morello R, Zabel B, Winterpacht A, Johnson RL, Lee B, Oberg KC, Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004 Jul;4(4):397-405
14J:173840 El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D, Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15;353(2):242-58
2J:163648 Fairbridge NA, Dawe CE, Niri FH, Kooistra MK, King-Jones K, McDermid HE, Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):619-25
2J:160589 Freyer L, Morrow BE, Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle. Dev Dyn. 2010 Jun;239(6):1708-22
7J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
2J:153202 Gerber SD, Steinberg F, Beyeler M, Villiger PM, Trueb B, The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. Dev Biol. 2009 Nov 1;335(1):106-19
1J:122815 Giordani J, Bajard L, Demignon J, Daubas P, Buckingham M, Maire P, Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11310-11315
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1J:193110 Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ, Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
3J:119948 Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX, Maire P, Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16
6J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
1J:180774 Grimsley-Myers CM, Sipe CW, Wu DK, Lu X, Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol. 2012 Feb 15;362(2):172-86
2J:87048 Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA, Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004 Jan;131(1):165-79
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
8J:172023 Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X, A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
1J:192707 He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT, Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 3;110(3):406-15
1J:202450 He F, Soriano P, A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet. 2013 Sep;9(9):e1003851
2J:187741 Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ, Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 2012 Sep 15;26(18):2088-102
6J:170495 Ikeda K, Kageyama R, Suzuki Y, Kawakami K, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54(10):1453-64
10J:126356 Ikeda K, Ookawara S, Sato S, Ando Z, Kageyama R, Kawakami K, Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol. 2007 Nov 1;311(1):53-68
4J:166952 Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS, Dachshund homologues play a conserved role in islet cell development. Dev Biol. 2010 Dec 15;348(2):143-52
3J:172983 Kobayashi H, Kawakami K, Asashima M, Nishinakamura R, Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech Dev. 2007 Apr;124(4):290-303
3J:114468 Konishi Y, Ikeda K, Iwakura Y, Kawakami K, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
1J:95309 Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N, Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development. 2005 Feb;132(3):469-78
1*J:82459 Laclef C, Hamard G, Demignon J, Souil E, Houbron C, Maire P, Altered myogenesis in Six1-deficient mice. Development. 2003 May;130(10):2239-52
9*J:84417 Laclef C, Souil E, Demignon J, Maire P, Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. Mech Dev. 2003 Jun;120(6):669-79
1J:190460 Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, Maillet M, Pages G, Rudnicki M, Tajbakhsh S, Maire P, Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012 Sep 3;198(5):815-32
1*J:199481 Leung AW, Kent Morest D, Li JY, Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Dev Biol. 2013 Jul 15;379(2):208-20
3J:86619 Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
1*J:119031 Lillevali K, Haugas M, Matilainen T, Pussinen C, Karis A, Salminen M, Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mech Dev. 2006 Jun;123(6):415-29
1*J:93820 Lillevali K, Matilainen T, Karis A, Salminen M, Partially overlapping expression of Gata2 and Gata3 during inner ear development. Dev Dyn. 2004 Dec;231(4):775-81
2J:155594 Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F, Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet. 2009 Dec;41(12):1295-302
1J:202226 Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH, Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1;382(1):110-23
5J:155993 McCoy EL, Kawakami K, Ford HL, Coletta RD, Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland. Oral Dis. 2009 Sep;15(6):407-13
2*J:130227 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI, Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan;8(2):124-39
1*J:96463 Moraes F, Novoa A, Jerome-Majewska LA, Papaioannou VE, Mallo M, Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Mech Dev. 2005 Feb;122(2):199-212
7J:157941 Nie X, Sun J, Gordon RE, Cai CL, Xu PX, SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Development. 2010 Mar;137(5):755-65
2J:171473 Nie X, Xu J, El-Hashash A, Xu PX, Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol. 2011 Apr 1;352(1):141-51
1J:156719 Niro C, Demignon J, Vincent S, Liu Y, Giordani J, Sgarioto N, Favier M, Guillet-Deniau I, Blais A, Maire P, Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome. Dev Biol. 2010 Feb 15;338(2):168-82
5J:159508 Nonomura K, Takahashi M, Wakamatsu Y, Takano-Yamamoto T, Osumi N, Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development. J Anat. 2010 Jan;216(1):80-91
18*J:23775 Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P, Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
9*J:104488 Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K, Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
1J:69010 Ozaki H, Watanabe Y, Takahashi K, Kitamura K, Tanaka A, Urase K, Momoi T, Sudo K, Sakagami J, Asano M, Iwakura Y, Kawakami K, Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. Mol Cell Biol. 2001 May;21(10):3343-50
1J:142530 Pitera JE, Scambler PJ, Woolf AS, Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet. 2008 Dec 15;17(24):3953-64
2J:107078 Poladia DP, Kish K, Kutay B, Hains D, Kegg H, Zhao H, Bates CM, Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol. 2006 Mar 15;291(2):325-39
1J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
2J:100569 Sajithlal G, Zou D, Silvius D, Xu PX, Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol. 2005 Aug 15;284(2):323-36
4*J:163874 Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H, Kawakami K, Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR. Dev Biol. 2010 Aug 1;344(1):158-71
1J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
4J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
3J:145164 Soker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hoelter SM, Horsch M, Kallnik M, Kling E, Morth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, Hrabe de Angelis M, Graw J, Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol. 2008 Dec 22;8(1):118
11J:161718 Suzuki Y, Ikeda K, Kawakami K, Regulatory role of Six1 in the development of taste papillae. Cell Tissue Res. 2010 Mar;339(3):513-25
6J:165447 Suzuki Y, Ikeda K, Kawakami K, Expression of Six1 and Six4 in mouse taste buds. J Mol Histol. 2010 Oct;41(4-5):205-14
1J:160309 Vinagre T, Moncaut N, Carapuco M, Novoa A, Bom J, Mallo M, Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains. Dev Cell. 2010 Apr 20;18(4):655-61
5J:172391 Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL, Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One. 2011;6(4):e18723
7*J:178455 Wang C, Gargollo P, Guo C, Tang T, Mingin G, Sun Y, Li X, Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 1;360(1):186-94
1J:178355 Wang J, Kumar RM, Biggs VJ, Lee H, Chen Y, Kagey MH, Young RA, Abate-Shen C, The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. Dev Cell. 2011 Sep 13;21(3):575-88
1J:57313 Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
7*J:83432 Xu PX, Zheng W, Huang L, Maire P, Laclef C, Silvius D, Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94
2J:79848 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44
1*J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
3*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1J:84974 Zheng W, Huang L, Wei ZB, Silvius D, Tang B, Xu PX, The role of Six1 in mammalian auditory system development. Development. 2003 Sep;130(17):3989-4000
3J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
4J:94396 Zou D, Silvius D, Fritzsch B, Xu PX, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development. 2004 Nov;131(22):5561-72

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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory