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Gene Expression Literature Summary
Symbol
Name
ID
Efnb1
ephrin B1
MGI:102708

74 matching records from 74 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17.5 E18 E18.5 E A
In situ protein (section) 1 2 3 1 4 1 5 1 4 3 4 2 2 4 3 2 1 10
In situ RNA (section) 1 3 3 1 4 2 7 2 7 1 9 1 3 3 2 1 2 4
In situ RNA (whole mount) 1 1 1 1 5 1 4 1 2 1 2 3 1 2 1
In situ reporter (knock in) 1 1
Northern blot 1
Western blot 1 2 1 1 3 1 1 2 3 1 1 1 1 1 3
RT-PCR 1 2 1 2 2 1 2 2 1 1 1 6
cDNA clones 1 1 1 1 1 1
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Efnb1  ephrin B1   (Synonyms: Cek5-L, Cek5 ligand, EFL-3, Elk-L, Epl2, Eplg2, Lerk2, LERK-2, Stra1)
Results  Reference
1J:67296 Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R, The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 2001 Jan 12;104(1):57-69
3J:53085 Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R, Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999 Feb 1;13(3):295-306
4J:142774 Alfaro D, Munoz JJ, Garcia-Ceca J, Cejalvo T, Jimenez E, Zapata A, Alterations in the thymocyte phenotype of EphB-deficient mice largely affect the double negative cell compartment. Immunology. 2008 Sep;125(1):131-43
3J:196665 Arvanitis DN, Behar A, Tryoen-Toth P, Bush JO, Jungas T, Vitale N, Davy A, Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013 May;140(10):2082-92
1J:128980 Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM, Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep;35(1):70-5
2*J:60855 Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M, Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar;127(6):1231-41
7*J:28316 Bouillet P, Oulad-Abdelghani M, Vicaire S, Garnier JM, Schuhbaur B, Dolle P, Chambon P, Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
2*J:54097 Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R, EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999 Mar;22(3):511-24
1J:177885 Brunskill EW, Georgas K, Rumballe B, Little MH, Potter SS, Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
3J:150043 Bush JO, Soriano P, Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 1;23(13):1586-99
6J:163986 Bush JO, Soriano P, Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010 Sep 15;24(18):2068-80
2J:140400 Campbell TN, Davy A, Liu Y, Arcellana-Panlilio M, Robbins SM, Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1. Biochem Biophys Res Commun. 2008 Oct 24;375(3):362-6
1J:73073 Chapouton P, Schuurmans C, Guillemot F, Gotz M, The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum. Development. 2001 Dec;128(24):5149-59
1J:97008 Chen ZY, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R, Abnormal hippocampal axon bundling in EphB receptor mutant mice. J Neurosci. 2004 Mar 10;24(10):2366-74
2J:38663 Ciossek T, Ullrich A, Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1. Oncogene. 1997 Jan 9;14(1):35-43
4J:110732 Compagni A, Logan M, Klein R, Adams RH, Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 2003 Aug;5(2):217-30
1J:62565 Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B, EphB2 guides axons at the midline and is necessary for normal vestibular function [see comments]. Neuron. 2000 May;26(2):417-30
3*J:89008 Davy A, Aubin J, Soriano P, Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004 Mar 1;18(5):572-83
2J:115952 Davy A, Bush JO, Soriano P, Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006 Sep;4(10):e315
1J:143845 Davy A, Soriano P, Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol. 2007 Apr 1;304(1):182-93
1*J:73773 de Diego I, Kyriakopoulou K, Karagogeos D, Wassef M, Multiple influences on the migration of precerebellar neurons in the caudal medulla. Development. 2002 Jan;129(2):297-306
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:111207 Dionne MS, Brunet LJ, Eimon PM, Harland RM, Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol. 2002 Nov 15;251(2):283-93
3J:173636 Dravis C, Henkemeyer M, Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51
1J:116671 Dravis C, Wu T, Chumley MJ, Yokoyama N, Wei S, Wu DK, Marcus DC, Henkemeyer M, EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph. Hear Res. 2007 Jan;223(1-2):93-104
2J:60774 Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG, Sanes JR, Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. Neuron. 2000 Feb;25(2):295-306
14*J:36483 Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG, Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev Biol. 1996 Nov 1;179(2):382-401
1J:183770 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1;21(11):2524-37
1J:106994 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK, Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006 Mar 22;25(6):1242-52
2J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
3*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
1J:34200 Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R, Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996 Jul 12;86(1):35-46
1J:149620 Ho SK, Kovacevic N, Henkelman RM, Boyd A, Pawson T, Henderson JT, EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain. Neuroscience. 2009 Jun 2;160(4):784-95
4J:60835 Imondi R, Wideman C, Kaprielian Z, Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000 Apr;127(7):1397-410
4J:162837 Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK, Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep;55(9):2478-88
5J:172113 Jevince AR, Kadison SR, Pittman AJ, Chien CB, Kaprielian Z, Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol. 2006 Aug 10;497(5):734-50
2J:144306 Kadison SR, Makinen T, Klein R, Henkemeyer M, Kaprielian Z, EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. J Neurosci. 2006 Aug 30;26(35):8909-14
1J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
2J:68850 Lu Q, Sun EE, Klein RS, Flanagan JG, Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001 Apr 6;105(1):69-79
1J:176643 Luria V, Krawchuk D, Jessell TM, Laufer E, Kania A, Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. Neuron. 2008 Dec 26;60(6):1039-53
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:104532 Mendes SW, Henkemeyer M, Liebl DJ, Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006 Jan 18;26(3):882-92
2J:89474 Morikawa Y, Cserjesi P, Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204
1*J:74240 Mui SH, Hindges R, O'Leary DD, Lemke G, Bertuzzi S, The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
1*J:156952 North HA, Karim A, Jacquin MF, Donoghue MJ, EphA4 is necessary for spatially selective peripheral somatosensory topography. Dev Dyn. 2010 Feb;239(2):630-8
3J:150346 North HA, Zhao X, Kolk SM, Clifford MA, Ziskind DM, Donoghue MJ, Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009 Jul;136(14):2467-76
4J:103329 Ogawa Y, Takebayashi H, Takahashi M, Osumi N, Iwasaki Y, Ikenaka K, Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord. Dev Neurosci. 2005;27(6):364-77
2J:37095 Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T, Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996 15;15(22):6035-49
1J:38350 Park S, Sanchez MP, The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
4*J:83513 Pickles JO, Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003 Apr;178(1-2):44-51
1J:187345 Piper M, Harris L, Barry G, Heng YH, Plachez C, Gronostajski RM, Richards LJ, Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 2011 Dec 1;519(17):3532-48
1J:145552 Risley M, Garrod D, Henkemeyer M, McLean W, EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009 Mar-Apr;126(3-4):230-9
2*J:57797 Rogers JH, Ciossek T, Menzel P, Pasquale EB, Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mech Dev. 1999 Sep;87(1-2):119-28
7*J:61450 Sapin V, Bouillet P, Oulad-Abdelghani M, Dastugue B, Chambon P, Dolle P, Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation. Mech Dev. 2000 Apr;92(2):295-9
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
3J:102106 Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HY, Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15;19(20):2412-7
19J:68841 Stuckmann I, Weigmann A, Shevchenko A, Mann M, Huttner WB, Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis. J Neurosci. 2001 Apr 15;21(8):2726-37
1J:111077 Takano-Maruyama M, Hase K, Fukamachi H, Kato Y, Koseki H, Ohno H, Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G163-70
1*J:88877 Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H, Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 2004 Mar 10;23(5):1075-88
3J:90813 Twigg SR, Kan R, Babbs C, Bochukova EG, Robertson SP, Wall SA, Morriss-Kay GM, Wilkie AO, Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8652-7
1*J:96034 van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der Gulden H, Jonkers J, Berns A, Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev. 2005 Feb 15;19(4):425-30
4*J:105961 van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG, Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006 Apr;6(4):353-9
2J:166759 Villasenor A, Chong DC, Henkemeyer M, Cleaver O, Epithelial dynamics of pancreatic branching morphogenesis. Development. 2010 Dec;137(24):4295-305
3J:183871 Villasenor A, Marty-Santos L, Dravis C, Fletcher P, Henkemeyer M, Cleaver O, EphB3 marks delaminating endocrine progenitor cells in the developing pancreas. Dev Dyn. 2012 May;241(5):1008-19
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:75288 Wang HU, Chen ZF, Anderson DJ, Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998 May 29;93(5):741-53
3J:121963 Wang W, Mullikin-Kilpatrick D, Crandall JE, Gronostajski RM, Litwack ED, Kilpatrick DL, Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules. J Neurosci. 2007 Jun 6;27(23):6115-27
2J:161965 Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Luthi U, Barberis A, Benjamin LE, Makinen T, Nobes CD, Adams RH, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010 May 27;465(7297):483-6
1J:139011 Wilkinson GA, Schittny JC, Reinhardt DP, Klein R, Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008 Aug;237(8):2220-34
1*J:85573 Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M, Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003 Sep 11;39(6):919-35
2J:95036 Yu G, Luo H, Wu Y, Wu J, EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem. 2004 Dec 31;279(53):55531-9
1J:178901 Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, Bolz J, Bidirectional EphrinB3/EphA4 Signaling Mediates the Segregation of Medial Ganglionic Eminence- and Preoptic Area-Derived Interneurons in the Deep and Superficial Migratory Stream. J Neurosci. 2011 Dec 14;31(50):18364-80
2J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory