Gene Expression Literature Summary

• Symbol: Runx3
• Name: runt related transcription factor 3
• ID: MGI:102672

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	A
In situ protein (section)							4		2	1	3		7		3		6		7		2		2	10
In situ RNA (section)							1		1	2	3	2	7	2	8	1	4	1	4	1	1	1	2	5
In situ RNA (whole mount)							1		1		2		2				1
In situ reporter (knock in)								1			4		5		2		2		1				1	2
Western blot																								1
RT-PCR	1	1	1	1	1	1	1		1		2		2		2		2		2		2		2	5
Nuclease S1											1													1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Runx3  runt related transcription factor 3   (Synonyms: AML2, Cbfa3)
Results	Reference
1	J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
2*	J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
1	J:119656 Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F, Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56
1	J:142362 Ben-Zvi A, Manor O, Schachner M, Yaron A, Tessier-Lavigne M, Behar O, The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008 Nov 19;28(47):12427-32
3*	J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4	J:160718 Dykes IM, Lanier J, Eng SR, Turner EE, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3
1	J:174563 Dykes IM, Tempest L, Lee SI, Turner EE, Brn3a and islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011 Jul 6;31(27):9789-99
1	J:160656 Eng SR, Dykes IM, Lanier J, Fedtsova N, Turner EE, POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP: the GenitoUrinary Development Molecular Anatomy Project, http://www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
4	J:114686 Hinoi E, Bialek P, Chen YT, Rached MT, Groner Y, Behringer RR, Ornitz DM, Karsenty G, Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev. 2006 Nov 1;20(21):2937-42
1	J:100886 Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S, A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
1	J:161851 Honma Y, Kawano M, Kohsaka S, Ogawa M, Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development. 2010 Jul;137(14):2319-28
3	J:79268 Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N, Ito Y, Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 2002 Oct;5(10):946-54
2	J:158761 Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S, Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010 Apr;137(7):1159-67
1	J:86539 Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E, Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol. 2003 Nov 10;163(3):609-23
4	J:106980 Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S, A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006 Feb 2;49(3):379-93
3	J:189922 Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P, Positional differences of axon growth rates between sensory neurons encoded by Runx3. EMBO J. 2012 Sep 12;31(18):3718-29
3	J:162039 Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC, Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer. Oncogene. 2010 Jun 10;29(23):3349-61
11	J:77764 Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, Bernstein Y, Goldenberg D, Xiao C, Fliegauf M, Kremer E, Otto F, Brenner O, Lev-Tov A, Groner Y, The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002 Jul 1;21(13):3454-63
4*	J:73303 Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y, Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev. 2001 Dec;109(2):413-7
3	J:75869 Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, ItoY, Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer. Cell. 2002 Apr 5;109(1):113-24
2	J:160257 Liakhovitskaia A, Lana-Elola E, Stamateris E, Rice DP, van 't Hof RJ, Medvinsky A, The essential requirement for Runx1 in the development of the sternum. Dev Biol. 2010 Apr 15;340(2):539-46
1	J:176467 Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T, Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 2011 Oct;49(4):673-82
4	J:134495 Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, Ozaki S, Shiga T, Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008 May;135(9):1703-11
4	J:99572 Raveh E, Cohen S, Levanon D, Groner Y, Gat U, Runx3 is involved in hair shape determination. Dev Dyn. 2005 Aug;233(4):1478-87
2*	J:71486 Rini D, Calabi F, Identification and comparative analysis of a second runx3 promoter. Gene. 2001 Jul 25;273(1):13-22
1	J:50165 Sato M, Morii E, Komori T, Kawahata H, Sugimoto M, Terai K, Shimizu H, Yasui T, Ogihara H, Yasui N, Ochi T, Kitamura Y, Ito Y, Nomura S, Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Oncogene. 1998 Sep 24;17(12):1517-25
5	J:142447 Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S, The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease. Arthritis Rheum. 2008 Sep;58(9):2764-75
1	J:171905 Scott A, Hasegawa H, Sakurai K, Yaron A, Cobb J, Wang F, Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci. 2011 May 4;31(18):6741-9
4	J:158404 Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T, Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci. 2010 Mar;43(3):296-307
9	J:124088 Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res. 2007 Aug;22(8):1260-70
8	J:76263 Stricker S, Fundele R, Vortkamp A, Mundlos S, Role of Runx genes in chondrocyte differentiation. Dev Biol. 2002 May 1;245(1):95-108
3	J:182750 Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H, Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation. Development. 2012 Mar;139(6):1125-32
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:112545 Wang XP, Aberg T, James MJ, Levanon D, Groner Y, Thesleff I, Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. J Dent Res. 2005 Feb;84(2):138-43
16	J:174179 Yamamoto H, Ito K, Kawai M, Murakami Y, Bessho K, Ito Y, Runx3 expression during mouse tongue and palate development. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul;288(7):695-9
6*	J:81317 Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I, Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev. 2002 Dec;119 Suppl 1:S107-10
4	J:89327 Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T, Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15;18(8):952-63
3	J:122558 Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, Chen Y, Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007 Jun 15;306(2):549-59
1	J:168525 Zhang S, Xiao Z, Luo J, He N, Mahlios J, Quarles LD, Dose-dependent effects of Runx2 on bone development. J Bone Miner Res. 2009 Nov;24(11):1889-904
3	J:125598 Zheng L, Iohara K, Ishikawa M, Into T, Takano-Yamamoto T, Matsushita K, Nakashima M, Runx3 negatively regulates Osterix expression in dental pulp cells. Biochem J. 2007 Jul 1;405(1):69-75
1	J:118268 Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B, Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19004-9
2	J:183949 Zou M, Li S, Klein WH, Xiang M, Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15;364(2):114-27