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Gene Expression Literature Summary
Symbol
Name
ID
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
MGI:101900

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E7.5 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18.5 E19 E19.5 E A
In situ protein (section) 1 1 1 2 3 1 4 2 2 1 1 3
In situ RNA (section) 2 1 1 2 1 1 3 1 2 2 6 4 1 4 1 3 2 1 1 2
In situ protein (whole mount) 1
Northern blot 1 1 2 2 2 3 1 2
Western blot 1 1 1 4
RT-PCR 2 1 1 2 2 2 1 6
cDNA clones 1 1 3
RNase protection 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Mmp14  matrix metallopeptidase 14 (membrane-inserted)   (Synonyms: Membrane type 1-MMP, MT1-MMP, sabe)
Results  Reference
12J:43437 Apte SS, Fukai N, Beier DR, Olsen BR, The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J Biol Chem. 1997 Oct 10;272(41):25511-7
1J:127043 Blavier L, Lazaryev A, Groffen J, Heisterkamp N, DeClerck YA, Kaartinen V, TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell. 2001 May;12(5):1457-66
5J:185530 Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z, MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis. Dev Cell. 2012 Jun 12;22(6):1176-90
2*J:67305 Colnot CI, Helms JA, A molecular analysis of matrix remodeling and angiogenesis during long bone development. Mech Dev. 2001 Feb;100(2):245-50
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4J:192183 Gkantidis N, Blumer S, Katsaros C, Graf D, Chiquet M, Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo. PLoS One. 2012;7(10):e47762
2J:202660 Gkantidis N, Katsaros C, Chiquet M, Detection of gelatinolytic activity in developing basement membranes of the mouse embryo head by combining sensitive in situ zymography with immunolabeling. Histochem Cell Biol. 2012 Oct;138(4):557-71
1J:167063 Gordon EJ, Rao S, Pollard JW, Nutt SL, Lang RA, Harvey NL, Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development. 2010 Nov;137(22):3899-910
2*J:84476 Guyot R, Magre S, Leduque P, Le Magueresse-Battistoni B, Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development. Dev Dyn. 2003 Jul;227(3):357-66
1J:94723 Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, Krane SM, Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7
1J:173235 Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z, MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J. 2011 Jun 1;30(11):2281-93
5J:120454 Kheradmand F, Rishi K, Werb Z, Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. J Cell Sci. 2002 Feb 15;115(Pt 4):839-48
2J:197476 Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Holscher C, Muller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M, Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013 Mar;16(3):273-80
11J:33235 Kinoh H, Sato H, Tsunezuka Y, Takino T, Kawashima A, Okada Y, Seiki M, MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis. J Cell Sci. 1996 May;109(Pt 5):953-9
1J:178303 Lee Y, Fryer JD, Kang H, Crespo-Barreto J, Bowman AB, Gao Y, Kahle JJ, Hong JS, Kheradmand F, Orr HT, Finegold MJ, Zoghbi HY, ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011 Oct 18;21(4):746-57
6J:74182 Legallicier B, Trugnan G, Murphy G, Lelongt B, Ronco P, Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. J Am Soc Nephrol. 2001 Nov;12(11):2358-69
3J:155594 Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F, Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet. 2009 Dec;41(12):1295-302
1J:194480 Ma S, Kwon HJ, Johng H, Zang K, Huang Z, Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
2J:95881 Oblander SA, Zhou Z, Galvez BG, Starcher B, Shannon JM, Durbeej M, Arroyo AG, Tryggvason K, Apte SS, Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol. 2005 Jan 1;277(1):255-69
1J:91198 Oh J, Takahashi R, Adachi E, Kondo S, Kuratomi S, Noma A, Alexander DB, Motoda H, Okada A, Seiki M, Itoh T, Itohara S, Takahashi C, Noda M, Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene. 2004 Jun 24;23(29):5041-8
1J:107674 Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M, The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001 Dec 14;107(6):789-800
1J:100747 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z, Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell. 2005 Jun;16(6):3028-39
12J:48622 Ota K, Stetler-Stevenson WG, Yang Q, Kumar A, Wada J, Kashihara N, Wallner EI, Kanwar YS, Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor. Kidney Int. 1998 Jul;54(1):131-42
1J:105134 Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M, Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Diabetes. 2005 Mar;54(3):694-701
1*J:56936 Robbins JR, McGuire PG, Wehrle-Haller B, Rogers SL, Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration. Dev Biol. 1999 Aug 15;212(2):255-63
2J:103331 Ryu J, Vicencio AG, Yeager ME, Kashgarian M, Haddad GG, Eickelberg O, Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost. 2005 Jul;94(1):175-83
2J:117794 Sakakura Y, Hosokawa Y, Tsuruga E, Irie K, Nakamura M, Yajima T, Constributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones. Cell Tissue Res. 2006 Apr;328(1):137-51
1J:181974 Seo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T, Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
3*J:138322 Smith L, Wagner TE, Huizar I, Schnapp LM, uPARAP expression during murine lung development. Gene Expr Patterns. 2008 Sep;8(7-8):486-93
4J:84595 Solberg H, Rinkenberger J, Dano K, Werb Z, Lund LR, A functional overlap of plasminogen and MMPs regulates vascularization during placental development. Development. 2003 Sep;130(18):4439-50
5J:167396 Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K, Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
1J:125052 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H, Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63
1J:132462 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH, Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17;279(51):53848-56
1J:102932 Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N, Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6
8J:85488 Yoshiba N, Yoshiba K, Stoetzel C, Perrin-Schmitt F, Cam Y, Ruch JV, Lesot H, Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. Dev Dyn. 2003 Sep;228(1):105-12

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory