Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits G-rich single-stranded DNA binding activity and ribosome binding activity. Involved in negative regulation of transcription by RNA polymerase II; neuromuscular process; and spinal cord motor neuron differentiation. Localizes to several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and nervous system. Used to study distal spinal muscular atrophy 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and distal spinal muscular atrophy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2).