Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of cytokine production; and regulation of apoptotic process. Predicted to localize to cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Orthologous to human JAK3 (Janus kinase 3).