Automated description from the Alliance of Genome Resources
Exhibits protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of cytokine production; and regulation of apoptotic process. Predicted to localize to the cytoplasm. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Human ortholog(s) of this gene implicated in adult T-cell leukemia; juvenile myelomonocytic leukemia; megakaryocytic leukemia; and precursor T-lymphoblastic lymphoma/leukemia. Orthologous to human JAK3 (Janus kinase 3).