Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pyy. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pyy
  • participates in the following biological processes:
    • eating behavior ^[1]
  • performs the following molecular functions:
    • neuropeptide hormone activity ^[1]
  • is located in the following cellular components:
    • extracellular space ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pyy:
  • participates in the following biological processes:
    • negative regulation of response to food
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Pyy encodes a protein or proteins that contain the following InterPro domains: Pancreatic hormone-like, Pancreatic hormone-like, conserved site, indicating that the gene product:
  • performs the following molecular functions:
    • hormone activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pyy indicates that it:
  • performs the following molecular functions:
    • hormone activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Hnasko TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res, 1023:309-18. (PubMed:15374756)
2. Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130:456-69. (PubMed:17693256)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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