Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including K48-linked polyubiquitin modification-dependent protein binding activity; adenyl ribonucleotide binding activity; and ubiquitin-specific protease binding activity. Involved in several processes, including aggresome assembly; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Localizes to several cellular components, including ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; genitourinary system; gut; and liver. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein).