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Gene Ontology Classifications
valosin containing protein

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GO curators for mouse genes have assigned the following annotations to the gene product of Vcp. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Boeddrich A et al. (2006) An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J, 25:1547-58. (PubMed:16525503)
  2. Boyault C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev, 21:2172-81. (PubMed:17785525)
  3. Boyault C et al. (2006) HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J, 25:3357-66. (PubMed:16810319)
  4. Dai RM et al. (2001) Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat Cell Biol, 3:740-4. (PubMed:11483959)
  5. Dreveny I et al. (2004) Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J, 23:1030-9. (PubMed:14988733)
  6. Glinka T et al. (2014) Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. Biochem J, 457:253-61. (PubMed:24160817)
  7. Heo JM et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell, 40:465-80. (PubMed:21070972)
  8. Kaneko C et al. (2003) Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a. Biochem Biophys Res Commun, 300:297-304. (PubMed:12504083)
  9. Kaneko Y et al. (2010) Isolation of a point-mutated p47 lacking binding affinity to p97ATPase. FEBS Lett, 584:3873-7. (PubMed:20691684)
  10. Li G et al. (2006) The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A, 103:8348-53. (PubMed:16709668)
  11. Liang G et al. (2008) Polycystin-2 is regulated by endoplasmic reticulum-associated degradation. Hum Mol Genet, 17:1109-19. (PubMed:18178578)
  12. Lo JC et al. (2012) RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet, 8:e1002969. (PubMed:23055941)
  13. Marutani T et al. (2011) ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochim Biophys Acta, 1810:790-8. (PubMed:21600962)
  14. Meyer HH et al. (2000) A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J, 19:2181-92. (PubMed:10811609)
  15. Rao RV et al. (2004) Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem, 279:177-87. (PubMed:14561754)
  16. Seigneurin-Berny D et al. (2001) Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways. Mol Cell Biol, 21:8035-44. (PubMed:11689694)
  17. Werner HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci, 27:7717-30. (PubMed:17634366)
  18. Ye Y et al. (2003) Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol, 162:71-84. (PubMed:12847084)
  19. Ye Y et al. (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature, 429:841-7. (PubMed:15215856)
  20. Yoshida Y et al. (2005) Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. EMBO Rep, 6:239-44. (PubMed:15723043)
  21. Zhao G et al. (2009) An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation. Proc Natl Acad Sci U S A, 106:16197-202. (PubMed:19805280)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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