Automated description from the Alliance of Genome Resources (Release 4.0)
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in basement membrane; neuromuscular junction; and sarcolemma. Is active in synaptic cleft. Is expressed in several structures, including alimentary system; basement membrane; metanephros; musculature; and skin. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2).