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Gene Ontology Classifications
Symbol
Name
ID
Rab23
RAB23, member RAS oncogene family
MGI:99833

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rab23. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Eggenschwiler JT et al. (2001) Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature, 412:194-8. (PubMed:11449277)
  2. Eggenschwiler JT et al. (2006) Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol, 290:1-12. (PubMed:16364285)
  3. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
  4. Gunther T et al. (1994) Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development, 120:3119-30. (PubMed:7720556)
  5. Guo A et al. (2006) Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization. J Neurosci Res, 83:1118-27. (PubMed:16463280)
  6. Hoover AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development, 135:4049-58. (PubMed:19004860)
  7. Huangfu D et al. (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature, 426:83-7. (PubMed:14603322)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory