Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rab23. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rab23
  • participates in the following biological processes:
    • embryonic digit morphogenesis ^[3]
    • negative regulation of proteolysis ^[2]
    • nervous system development ^[1]
    • signal transduction ^[1]
    • spinal cord dorsal/ventral patterning ^{[2, 3]}
• Researchers have inferred, based on genetic interactions, that the gene product of Rab23
  • participates in the following biological processes:
    • regulation of smoothened signaling pathway based on interactions with C2cd3 ^[4]
    • spinal cord dorsal/ventral patterning based on interactions with Gli2, Gli3, Ift172 ^{[2, 5]}

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rab23:
  • participates in the following biological processes:
    • autophagic vacuole assembly
    • cellular defense response
    • craniofacial suture morphogenesis
    • GTP catabolic process
    • negative regulation of transcription factor import into nucleus
  • performs the following molecular functions:
    • GTPase activity
  • is located in the following cellular components:
    • autophagic vacuole
    • cytoplasm

---

Summary text based on GO annotations supported by structural data

• Rab23 encodes a protein or proteins that contain the following InterPro domains: Small GTP-binding protein domain, Small GTPase superfamily, Small GTPase superfamily, Rab type, indicating that the gene product:
  • participates in the following biological processes:
    • protein transport
    • small GTPase mediated signal transduction
  • performs the following molecular functions:
    • GTP binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rab23 indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • performs the following molecular functions:
    • GTP binding
    • nucleotide binding
  • is located in the following cellular components:
    • membrane
    • plasma membrane

---

References

1. Eggenschwiler JT et al. (2001) Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature, 412:194-8. (PubMed:11449277)
2. Eggenschwiler JT et al. (2006) Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol, 290:1-12. (PubMed:16364285)
3. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
4. Hoover AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development, 135:4049-58. (PubMed:19004860)
5. Huangfu D et al. (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature, 426:83-7. (PubMed:14603322)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---