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Gene Ontology Classifications
Symbol
Name
ID
Slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
MGI:99828

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc7a2. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 4, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bodoy S et al. (2005) Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem, 280:12002-11. (PubMed:15659399)
  2. Closs EI et al. (1993) Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem, 268:7538-44. (PubMed:8385111)
  3. Kavanaugh MP et al. (1994) Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. J Biol Chem, 269:15445-50. (PubMed:8195186)
  4. Kudo H et al. (1994) Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses. Exp Cell Res, 212:219-24. (PubMed:8187816)
  5. Manner CK et al. (2003) CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes. J Neurochem, 85:476-82. (PubMed:12675924)
  6. Nicholson B et al. (2001) Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J Biol Chem, 276:15881-5. (PubMed:11278602)
  7. Rothenberg ME et al. (2006) Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A, 103:14895-900. (PubMed:17003120)
  8. Yeramian A et al. (2006) Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol, 176:5918-24. (PubMed:16670299)
  9. Yeramian A et al. (2006) Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. Eur J Immunol, 36:1516-26. (PubMed:16703566)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory