Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc7a2. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 4, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc7a2
  • participates in the following biological processes:
    • arginine transport ^{[2, 3]}
    • L-amino acid transport ^[1]
    • lysine transport ^[2]
    • ornithine transport ^[2]
  • performs the following molecular functions:
    • arginine transmembrane transporter activity ^{[2, 3]}
    • high affinity arginine transmembrane transporter activity ^[3]
    • L-amino acid transmembrane transporter activity ^[1]
    • L-lysine transmembrane transporter activity ^[2]
    • L-ornithine transmembrane transporter activity ^[2]
  • is located in the following cellular components:
    • integral component of membrane ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc7a2
  • participates in the following biological processes:
    • arginine transport ^{[5, 6]}
    • L-alpha-amino acid transmembrane transport ^[5]
    • macrophage activation ^[9]
    • nitric oxide biosynthetic process ^[5]
    • nitric oxide production involved in inflammatory response ^{[6, 7]}
    • regulation of inflammatory response ^[7]
    • regulation of macrophage activation ^[8]
  • performs the following molecular functions:
    • arginine transmembrane transporter activity ^[6]
    • L-amino acid transmembrane transporter activity ^[5]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Slc7a2
  • is located in the following cellular components:
    • integral component of membrane ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc7a2:
  • participates in the following biological processes:
    • amino acid transmembrane transport
    • arginine transport
  • performs the following molecular functions:
    • arginine transmembrane transporter activity

---

Summary text based on GO annotations supported by structural data

• Slc7a2 encodes a protein or proteins that contain the following InterPro domains: Amino acid/polyamine transporter I, Cationic amino acid transport permease, indicating that the gene product:
  • participates in the following biological processes:
    • amino acid transport
  • performs the following molecular functions:
    • amino acid transmembrane transporter activity
  • is located in the following cellular components:
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc7a2 indicates that it:
  • participates in the following biological processes:
    • amino acid transport
    • transport
  • is located in the following cellular components:
    • membrane

---

References

1. Bodoy S et al. (2005) Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem, 280:12002-11. (PubMed:15659399)
2. Closs EI et al. (1993) Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem, 268:7538-44. (PubMed:8385111)
3. Kavanaugh MP et al. (1994) Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. J Biol Chem, 269:15445-50. (PubMed:8195186)
4. Kudo H et al. (1994) Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses. Exp Cell Res, 212:219-24. (PubMed:8187816)
5. Manner CK et al. (2003) CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes. J Neurochem, 85:476-82. (PubMed:12675924)
6. Nicholson B et al. (2001) Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J Biol Chem, 276:15881-5. (PubMed:11278602)
7. Rothenberg ME et al. (2006) Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A, 103:14895-900. (PubMed:17003120)
8. Yeramian A et al. (2006) Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol, 176:5918-24. (PubMed:16670299)
9. Yeramian A et al. (2006) Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. Eur J Immunol, 36:1516-26. (PubMed:16703566)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---