Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and histone acetyltransferase activity. Involved in several processes, including negative regulation of glucocorticoid receptor signaling pathway; regulation of gene expression; and regulation of insulin secretion. Acts upstream of or within circadian rhythm. Located in chromatoid body and nucleus. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including alimentary system; ear; early conceptus; genitourinary system; and nervous system. Used to study bipolar disorder; diabetes mellitus; and sleep disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CLOCK (clock circadian regulator).