Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits protease binding activity; ryanodine-sensitive calcium-release channel activity; and voltage-gated calcium channel activity. Involved in several processes, including animal organ development; cellular response to caffeine; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Localizes to T-tubule; endoplasmic reticulum; and junctional membrane complex. Is expressed in several structures, including brain; embryo mesenchyme; heart; sciatic nerve; and skeletal musculature. Used to study central core myopathy and malignant hyperthermia. Human ortholog(s) of this gene implicated in central core myopathy and malignant hyperthermia. Orthologous to human RYR1 (ryanodine receptor 1).