Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acan. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acan
  • is located in the following cellular components:
    • basement membrane ^[2]
    • extracellular matrix ^[1]
    • proteinaceous extracellular matrix ^[5]
• The gene product of Acan has been shown to bind to the gene products of Fbln1. ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acan
  • participates in the following biological processes:
    • cartilage condensation ^[4]
    • chondrocyte development ^[6]
    • collagen fibril organization ^[4]
    • proteoglycan biosynthetic process ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acan:
  • participates in the following biological processes:
    • negative regulation of cell migration
  • performs the following molecular functions:
    • calcium ion binding
  • is located in the following cellular components:
    • perineuronal net
    • proteinaceous extracellular matrix

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Summary text based on GO annotations supported by structural data

• Acan encodes a protein or proteins that contain the following InterPro domains: C-type lectin, C-type lectin fold, C-type lectin, conserved site, C-type lectin-like, Complement control module, Immunoglobulin V-set, Immunoglobulin V-set, subgroup, Immunoglobulin-like, Immunoglobulin-like fold, Immunoglobulin/major histocompatibility complex, conserved site, Link, Sushi/SCR/CCP, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • performs the following molecular functions:
    • carbohydrate binding
    • hyaluronic acid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acan indicates that it:
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region

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References

1. Kluppel M et al. (2005) Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development, 132:3989-4003. (PubMed:16079159)
2. Lee NV et al. (2005) Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem, 280:34796-804. (PubMed:16061471)
3. Liu Y et al. (1997) Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. J Biol Chem, 272:29880-5. (PubMed:9368062)
4. Seegmiller RE et al. (1988) Histochemical, immunofluorescence, and ultrastructural differences in fetal cartilage among three genetically distinct chondrodystrophic mice. Teratology, 38:579-92. (PubMed:3070812)
5. Shibata S et al. (2003) In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage. J Anat, 203:425-32. (PubMed:14620382)
6. Wai AW et al. (1998) Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant. Dev Genet, 22:349-58. (PubMed:9664687)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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