Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including cartilage development; collagen fibril organization; and proteoglycan biosynthetic process. Located in basement membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Is expressed in several structures, including genitourinary system; limb; lower jaw; sensory organ; and skeletal system. Used to study achondroplasia. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan).