Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aldh2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aldh2
  • is located in the following cellular components:
    • mitochondrion ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aldh2:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • aldehyde dehydrogenase (NAD) activity
    • identical protein binding
  • is located in the following cellular components:
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Aldh2 encodes a protein or proteins that contain the following InterPro domains: Aldehyde dehydrogenase domain, Aldehyde dehydrogenase, C-terminal, Aldehyde dehydrogenase, conserved site, Aldehyde dehydrogenase, N-terminal, Aldehyde/histidinol dehydrogenase, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • oxidoreductase activity
    • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aldh2 indicates that it:
  • performs the following molecular functions:
    • oxidoreductase activity

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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