Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fgb. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fgb
  • is located in the following cellular components:
    • cell cortex ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fgb:
  • participates in the following biological processes:
    • response to calcium ion
  • performs the following molecular functions:
    • chaperone binding
    • eukaryotic cell surface binding
  • is located in the following cellular components:
    • blood microparticle
    • cytoplasm
    • external side of plasma membrane
    • extracellular space
    • platelet alpha granule

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Summary text based on GO annotations supported by structural data

• Fgb encodes a protein or proteins that contain the following InterPro domains: Fibrinogen, alpha/beta/gamma chain, C-terminal globular, Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1, Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2, Fibrinogen, alpha/beta/gamma chain, coiled coil domain, Fibrinogen, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • platelet activation
    • protein polymerization
    • signal transduction
  • performs the following molecular functions:
    • protein binding, bridging
    • receptor binding
  • is located in the following cellular components:
    • fibrinogen complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fgb indicates that it:
  • participates in the following biological processes:
    • blood coagulation
    • hemostasis
  • is located in the following cellular components:
    • extracellular region

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References

1. Tolhurst G et al. (2005) Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood, 106:1644-51. (PubMed:15914557)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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