Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables IkappaB kinase activity. Involved in canonical NF-kappaB signal transduction; positive regulation of interferon-alpha production; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and response to muscle stretch. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).