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Gene Ontology Classifications
conserved helix-loop-helix ubiquitous kinase

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GO curators for mouse genes have assigned the following annotations to the gene product of Chuk. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Cao Y et al. (2001) IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell, 107:763-75. (PubMed:11747812)
  2. Chaisson ML et al. (2004) Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J Biol Chem, 279:54841-8. (PubMed:15485831)
  3. Chen RA et al. (2008) Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog, 4:e22. (PubMed:18266467)
  4. Cui J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell, 141:483-96. (PubMed:20434986)
  5. Hoshino K et al. (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature, 440:949-53. (PubMed:16612387)
  6. Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One, 5:e11380. (PubMed:20614026)
  7. Makowski L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 280:12888-95. (PubMed:15684432)
  8. McKenzie FR et al. (2000) Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. Mol Cell Biol, 20:2635-49. (PubMed:10733566)
  9. Mohamed JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J, 24:3330-40. (PubMed:20442316)
  10. Neely RJ et al. (2011) The RET/PTC3 oncogene activates classical NF-kappaB by stabilizing NIK. Oncogene, 30:87-96. (PubMed:20818435)
  11. Ohazama A et al. (2004) A dual role for Ikk alpha in tooth development. Dev Cell, 6:219-27. (PubMed:14960276)
  12. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  13. Pfaller CK et al. (2008) Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. J Virol, 82:12365-73. (PubMed:18922877)
  14. Richardson RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet, 38:1329-34. (PubMed:17041603)
  15. Song H et al. (2012) Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J, 31:1147-59. (PubMed:22227519)
  16. Teo H et al. (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol, 12:758-67. (PubMed:20622870)
  17. Vacca A et al. (2006) Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J, 25:1000-8. (PubMed:16498412)
  18. Yamaguchi M et al. (2014) An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction. FEBS Lett, 588:28-34. (PubMed:24269682)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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