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Gene Ontology Classifications
Symbol
Name
ID
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
MGI:99480

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cebpa. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
References
  1. . () , :. (PubMed:)
  2. Antes TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine J Biol Chem, 275:26637-48. (PubMed:10859308)
  3. Asaki T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol Cell Endocrinol, 218:119-28. (PubMed:15130516)
  4. Begay V et al. (2004) Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol, 24:9744-51. (PubMed:15509779)
  5. Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem, 277:30998-1004. (PubMed:12055200)
  6. Carmona MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem, 277:21489-98. (PubMed:11940593)
  7. Chiang MC et al. (2007) Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum Mol Genet, 16:483-98. (PubMed:17213233)
  8. Fazio S et al. (1999) Recycling of apolipoprotein E in mouse liver. J Biol Chem, 274:8247-53. (PubMed:10075730)
  9. Fei Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem, 286:27761-8. (PubMed:21669876)
  10. Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature, 417:563-7. (PubMed:12037571)
  11. Heath V et al. (2004) C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood, 104:1639-47. (PubMed:15073037)
  12. Ichida F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem, 279:34015-22. (PubMed:15175325)
  13. Juan T et al. (2009) Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res, 50:534-45. (PubMed:18974039)
  14. Kajimura S et al. (2009) Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature, 460:1154-8. (PubMed:19641492)
  15. Kennell JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol, 23:5366-75. (PubMed:12861022)
  16. Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev, 20:2293-305. (PubMed:16912278)
  17. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
  18. Martis PC et al. (2006) C/EBP{alpha} is required for lung maturation at birth. Development, 133:1155-64. (PubMed:16467360)
  19. Numata A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem, 280:12621-9. (PubMed:15664994)
  20. Piwien Pilipuk G et al. (2003) Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J Biol Chem, 278:35668-77. (PubMed:12821655)
  21. Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science, 289:950-3. (PubMed:10937998)
  22. Sekine K et al. (2007) Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J, 26:3607-15. (PubMed:17627282)
  23. Shiojiri N et al. (2004) Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development. J Hepatol, 41:790-8. (PubMed:15519652)
  24. Tang QQ et al. (2003) Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci U S A, 100:44-9. (PubMed:12502791)
  25. Timchenko NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol, 19:2936-45. (PubMed:10082561)
  26. Tomita T et al. (2008) CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem, 283:25617-27. (PubMed:18632661)
  27. Vasseur S et al. (1999) Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J, 343 Pt 2:377-83. (PubMed:10510303)
  28. Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell, 16:2039-48. (PubMed:15673614)
  29. Wang X et al. (2008) AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol, 183:37-48. (PubMed:18824566)
  30. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)
  31. Yamasaki H et al. (2006) Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development, 133:4233-43. (PubMed:17021047)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory