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Gene Ontology Classifications
CCAAT/enhancer binding protein (C/EBP), alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cebpa. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Antes TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine J Biol Chem, 275:26637-48. (PubMed:10859308)
  2. Asaki T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol Cell Endocrinol, 218:119-28. (PubMed:15130516)
  3. Begay V et al. (2004) Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. Mol Cell Biol, 24:9744-51. (PubMed:15509779)
  4. Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem, 277:30998-1004. (PubMed:12055200)
  5. Carmona MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem, 277:21489-98. (PubMed:11940593)
  6. Chiang MC et al. (2007) Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Hum Mol Genet, 16:483-98. (PubMed:17213233)
  7. Falix FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol, 396:201-13. (PubMed:25446530)
  8. Faure AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res, 22:2163-75. (PubMed:22780989)
  9. Fazio S et al. (1999) Recycling of apolipoprotein E in mouse liver. J Biol Chem, 274:8247-53. (PubMed:10075730)
  10. Fei Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J Biol Chem, 286:27761-8. (PubMed:21669876)
  11. Flodby P et al. (1996) Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem, 271:24753-60. (PubMed:8798745)
  12. Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature, 417:563-7. (PubMed:12037571)
  13. Heath V et al. (2004) C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood, 104:1639-47. (PubMed:15073037)
  14. Ichida F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem, 279:34015-22. (PubMed:15175325)
  15. Juan T et al. (2009) Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res, 50:534-45. (PubMed:18974039)
  16. Kajimura S et al. (2009) Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature, 460:1154-8. (PubMed:19641492)
  17. Kennell JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol, 23:5366-75. (PubMed:12861022)
  18. Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev, 20:2293-305. (PubMed:16912278)
  19. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
  20. Martis PC et al. (2006) C/EBP{alpha} is required for lung maturation at birth. Development, 133:1155-64. (PubMed:16467360)
  21. Muller C et al. (2004) The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J Biol Chem, 279:7353-8. (PubMed:14660596)
  22. Numata A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem, 280:12621-9. (PubMed:15664994)
  23. Pedersen TA et al. (2007) Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J, 26:1081-93. (PubMed:17290224)
  24. Piwien Pilipuk G et al. (2003) Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J Biol Chem, 278:35668-77. (PubMed:12821655)
  25. Porse BT et al. (2001) E2f repression by c/ebpalpha is required for adipogenesis and granulopoiesis in vivo. Cell, 107:247-58. (PubMed:11672531)
  26. Qiao L et al. (2006) SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem, 281:39915-24. (PubMed:17090532)
  27. Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science, 289:950-3. (PubMed:10937998)
  28. Samuelsson L et al. (1991) The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J, 10:3787-93. (PubMed:1935900)
  29. Sekine K et al. (2007) Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J, 26:3607-15. (PubMed:17627282)
  30. Shiojiri N et al. (2004) Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development. J Hepatol, 41:790-8. (PubMed:15519652)
  31. Tang QQ et al. (2003) Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci U S A, 100:44-9. (PubMed:12502791)
  32. Timchenko NA et al. (1999) C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol, 19:2936-45. (PubMed:10082561)
  33. Tomita T et al. (2008) CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem, 283:25617-27. (PubMed:18632661)
  34. Vasseur S et al. (1999) Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J, 343 Pt 2:377-83. (PubMed:10510303)
  35. Verbeek W et al. (1999) C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Blood, 93:3327-37. (PubMed:10233885)
  36. Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell, 16:2039-48. (PubMed:15673614)
  37. Wang GL et al. (2004) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev, 18:912-25. (PubMed:15107404)
  38. Wang X et al. (2008) AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol, 183:37-48. (PubMed:18824566)
  39. Wu Y et al. (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab, 295:E205-15. (PubMed:18492766)
  40. Yamasaki H et al. (2006) Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development, 133:4233-43. (PubMed:17021047)
  41. Zhang P et al. (2004) Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity, 21:853-63. (PubMed:15589173)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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