Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits enzyme binding activity. Involved in several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Localizes to nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3).