Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables enzyme binding activity. Involved in Notch signaling pathway and positive regulation of smooth muscle cell proliferation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3).