Automated description from the Alliance of Genome Resources
Exhibits enzyme binding activity. Involved in several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Localizes to the plasma membrane. Used to study CADASIL 1 and acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1 and infantile myofibromatosis. Orthologous to human NOTCH3 (notch receptor 3).