Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables steroid binding activity. Involved in several processes, including angiotensin-activated signaling pathway; potassium ion homeostasis; and regulation of blood volume by renal aldosterone. Acts upstream of or within cellular sodium ion homeostasis and renal sodium excretion. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).