About   Help   FAQ
Gene Ontology Classifications
myocyte enhancer factor 2C

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mef2c. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 1, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Agarwal P et al. (2011) The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development, 138:2555-65. (PubMed:21610032)
  2. Akhtar MW et al. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS One, 7:e34863. (PubMed:22496871)
  3. Al Madhoun AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J, 30:2477-89. (PubMed:21556048)
  4. Angelelli C et al. (2008) Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res, 36:915-28. (PubMed:18086704)
  5. Arnold MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell, 12:377-89. (PubMed:17336904)
  6. Barbosa AC et al. (2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A, 105:9391-6. (PubMed:18599438)
  7. Bi W et al. (1999) The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol, 211:255-67. (PubMed:10395786)
  8. Black BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem, 271:26659-63. (PubMed:8900141)
  9. Creemers EE et al. (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell, 23:83-96. (PubMed:16818234)
  10. Dechesne CA et al. (1994) E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol Cell Biol, 14:5474-86. (PubMed:8035824)
  11. Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem, 273:25371-80. (PubMed:9738004)
  12. Fu W et al. (2006) MEF2C mediates the activation induced cell death (AICD) of macrophages. Cell Res, 16:559-65. (PubMed:16775627)
  13. Gekas C et al. (2009) Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood, 113:3461-71. (PubMed:19211936)
  14. Gunther S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res, 32:791-802. (PubMed:14762206)
  15. Han TH et al. (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol Cell Biol, 15:2907-15. (PubMed:7760790)
  16. Hosking BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun, 287:493-500. (PubMed:11554755)
  17. Ieda M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell, 142:375-86. (PubMed:20691899)
  18. Johnnidis JB et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature, 451:1125-9. (PubMed:18278031)
  19. Jung SY et al. (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem Biophys Res Commun, 396:238-45. (PubMed:20399744)
  20. Khiem D et al. (2008) A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A, 105:17067-72. (PubMed:18955699)
  21. Kobayashi N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells, 12:375-85. (PubMed:17352741)
  22. Kolodziejczyk SM et al. (1999) MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr Biol, 9:1203-6. (PubMed:10531040)
  23. Kuratomi S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res, 83:682-7. (PubMed:19477969)
  24. Lazaro JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev, 16:1792-805. (PubMed:12130539)
  25. Li H et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A, 105:9397-402. (PubMed:18599437)
  26. Li Z et al. (2008) Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci, 28:6557-68. (PubMed:18579729)
  27. Lin Q et al. (1998) Requirement of the MADS-box transcription factor MEF2C for vascular development. Development, 125:4565-74. (PubMed:9778514)
  28. Lin Q et al. (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science, 276:1404-7. (PubMed:9162005)
  29. Liu GH et al. (2009) Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS One, 4:e7031. (PubMed:19753306)
  30. Liu N et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A, 104:20844-9. (PubMed:18093911)
  31. Lu J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol Cell, 6:233-44. (PubMed:10983972)
  32. Lynch J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol, 170:37-47. (PubMed:15998798)
  33. Martin JF et al. (1993) Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A, 90:5282-6. (PubMed:8506376)
  34. McKinsey TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature, 408:106-11. (PubMed:11081517)
  35. Micheli L et al. (2005) PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol Cell Biol, 25:2242-59. (PubMed:15743821)
  36. Molkentin JD et al. (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol, 16:3814-24. (PubMed:8668199)
  37. Nakagawa O et al. (2005) Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev, 19:2066-77. (PubMed:16140986)
  38. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  39. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  40. Phan D et al. (2005) BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development, 132:2669-78. (PubMed:15890826)
  41. Potthoff MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest, 117:2459-67. (PubMed:17786239)
  42. Potthoff MJ et al. (2007) Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol, 27:8143-51. (PubMed:17875930)
  43. Rajan S et al. (2011) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics, null:null. (PubMed:22147266)
  44. Sato H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem Biophys Res Commun, 214:468-74. (PubMed:7677753)
  45. Schuler A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood, 111:4532-41. (PubMed:18326819)
  46. Stehling-Sun S et al. (2009) Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol, 10:289-96. (PubMed:19169261)
  47. Stephens AS et al. (2011) Myocyte Enhancer Factor 2C, an Osteoblast Transcription Factor Identified by Dimethyl Sulfoxide (DMSO)-enhanced Mineralization. J Biol Chem, 286:30071-86. (PubMed:21652706)
  48. Verzi MP et al. (2007) The transcription factor MEF2C is required for craniofacial development. Dev Cell, 12:645-52. (PubMed:17420000)
  49. Vincentz JW et al. (2008) Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn, 237:3809-19. (PubMed:19035347)
  50. Vong L et al. (2006) MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev Dyn, 235:1809-21. (PubMed:16680724)
  51. Wei X et al. (2003) MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol, 33:2903-9. (PubMed:14515274)
  52. Wilker PR et al. (2008) Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol, 9:603-12. (PubMed:18438409)
  53. Xia S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development, 137:1075-84. (PubMed:20181743)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory