Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arf6. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Arf6
  • participates in the following biological processes:
    • positive regulation of establishment of protein localization to plasma membrane ^[3]
    • protein localization to cell surface ^[3]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • endosome ^[3]
    • plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Arf6
  • participates in the following biological processes:
    • apoptotic process ^[5]
    • establishment of epithelial cell polarity ^[2]
    • liver development ^[5]
    • regulation of dendritic spine development ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Arf6:
  • participates in the following biological processes:
    • cortical actin cytoskeleton organization
    • positive regulation of actin filament polymerization
    • regulation of dendritic spine development
    • regulation of filopodium assembly
    • regulation of Rac protein signal transduction
    • ruffle organization
  • performs the following molecular functions:
    • thioesterase binding
  • is located in the following cellular components:
    • cell cortex
    • early endosome
    • endosome
    • filopodium membrane
    • plasma membrane
    • recycling endosome
    • ruffle

---

Summary text based on GO annotations supported by structural data

• Arf6 encodes a protein or proteins that contain the following InterPro domains: Small GTP-binding protein domain, Small GTPase superfamily, ARF type, Small GTPase superfamily, ARF/SAR type, indicating that the gene product:
  • participates in the following biological processes:
    • small GTPase mediated signal transduction
  • is located in the following cellular components:
    • intracellular

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arf6 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • nervous system development
    • transport
    • vesicle-mediated transport
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • Golgi apparatus
    • membrane

---

References

1. Hosaka M et al. (1996) Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem, 120:813-9. (PubMed:8947846)
2. Ikenouchi J et al. (2010) FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A, 107:748-53. (PubMed:20080746)
3. Kagan JC et al. (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell, 125:943-55. (PubMed:16751103)
4. Miyazaki H et al. (2005) The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Lett, 579:6834-8. (PubMed:16325184)
5. Suzuki T et al. (2006) Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol, 26:6149-56. (PubMed:16880525)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---