Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Etv4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Etv4
  • participates in the following biological processes:
    • positive regulation of gene expression ^[2]
    • positive regulation of transcription, DNA-dependent ^[4]
    • regulation of branching involved in mammary gland duct morphogenesis ^[3]
  • performs the following molecular functions:
    • DNA binding ^[7]
  • is located in the following cellular components:
    • intracellular ^[1]
• Researchers have inferred, based on physical interactions, that the gene product of Etv4
  • participates in the following biological processes:
    • positive regulation of transcription, DNA-dependent ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Etv4
  • participates in the following biological processes:
    • branching involved in mammary gland duct morphogenesis ^[5]
    • motor neuron axon guidance ^[6]
    • negative regulation of mammary gland epithelial cell proliferation ^[5]
    • stem cell differentiation ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Etv4:
  • is located in the following cellular components:
    • nucleolus

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Summary text based on GO annotations supported by structural data

• Etv4 encodes a protein or proteins that contain the following InterPro domains: Ets, PEA3-type ETS-domain transcription factor, N-terminal, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Etv4 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • is located in the following cellular components:
    • nucleus

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References

1. Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments] Neuron, 23:659-74. (PubMed:10482234)
2. Brent AE et al. (2004) FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development, 131:3885-96. (PubMed:15253939)
3. Chotteau-Lelievre A et al. (2003) PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro. Dev Biol, 259:241-57. (PubMed:12871699)
4. Firlej V et al. (2005) Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J Biol Chem, 280:887-98. (PubMed:15466854)
5. Kurpios NA et al. (2009) The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Dev Biol, 325:106-21. (PubMed:18977342)
6. Livet J et al. (2002) ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron, 35:877-92. (PubMed:12372283)
7. Shou Z et al. (2003) Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Gene, 302:83-94. (PubMed:12527199)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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