Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; cholesterol binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including neurogenesis; regulation of organelle organization; and regulation of transcription from RNA polymerase II promoter in response to stress. Localizes to several cellular components, including endoplasmic reticulum; integral component of endoplasmic reticulum membrane; and nucleus. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; head mesenchyme; and urinary system. Used to study hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human NFE2L1 (nuclear factor, erythroid 2 like 1).