Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables G protein-coupled receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor).