Automated description from the Alliance of Genome Resources (Release 7.0.0)
Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; regulation of DNA metabolic process; and voluntary musculoskeletal movement. Acts upstream of or within DNA repair and hippocampus development. Located in chromosome, telomeric region. Part of ERCC4-ERCC1 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1).