Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables oxidoreductase activity, acting on CH or CH2 groups. Involved in allantoin metabolic process and purine-containing compound catabolic process. Acts upstream of or within iron-sulfur cluster assembly; lactation; and regulation of epithelial cell differentiation. Located in sarcoplasmic reticulum. Is active in cytosol. Is expressed in several structures, including adrenal gland; genitourinary system; intestine; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria. Orthologous to human XDH (xanthine dehydrogenase).