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Gene Ontology Classifications
Symbol
Name
ID
Wt1
Wilms tumor 1 homolog
MGI:98968

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wt1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet, 18:2989-3001. (PubMed:19457926)
  2. Carpenter B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol Cell Biol, 24:537-49. (PubMed:14701728)
  3. Clipsham R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr Patterns, 4:3-14. (PubMed:14678822)
  4. Cohen JS. (1995) Provide fluoxetine information vital to clinicians. J Clin Psychiatry, 56:591. (PubMed:8530339)
  5. Dame C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood, 107:4282-90. (PubMed:16467207)
  6. Davies RC et al. (1998) WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev, 12:3217-25. (PubMed:9784496)
  7. Donovan MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet, 24:252-62. (PubMed:10322633)
  8. Du X et al. (2002) The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochim Biophys Acta, 1577:93-101. (PubMed:12151099)
  9. Green LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res, 37:431-40. (PubMed:19050011)
  10. Guo JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet, 11:651-9. (PubMed:11912180)
  11. Hammes A et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell, 106:319-29. (PubMed:11509181)
  12. Hewitt SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res, 55:5386-9. (PubMed:7585606)
  13. Hosono S et al. (1999) WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene, 18:417-27. (PubMed:9927198)
  14. Kreidberg JA et al. (1993) WT-1 is required for early kidney development. Cell, 74:679-91. (PubMed:8395349)
  15. Lee HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn, 238:812-25. (PubMed:19301398)
  16. Moore AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development, 126:1845-57. (PubMed:10101119)
  17. Natoli TA et al. (2004) Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol, 268:429-40. (PubMed:15063178)
  18. Niksic M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet, 13:463-71. (PubMed:14681305)
  19. Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A, 96:2931-6. (PubMed:10077614)
  20. Sainio K et al. (1997) Differential regulation of two sets of mesonephric tubules by WT-1. Development, 124:1293-9. (PubMed:9118800)
  21. Schumacher VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol, 22:1286-96. (PubMed:21719793)
  22. Smart N et al. (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature, 474:640-4. (PubMed:21654746)
  23. Val P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development, 134:2349-58. (PubMed:17537799)
  24. Wagner KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene, 305:217-23. (PubMed:12609742)
  25. Wagner KD et al. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J, 21:1398-405. (PubMed:11889045)
  26. Wagner N et al. (2005) Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev, 19:2631-42. (PubMed:16264195)
  27. Wagner N et al. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development, 132:1327-36. (PubMed:15716344)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory