Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wnt7a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Wnt7a
  • participates in the following biological processes:
    • asymmetric protein localization ^[7]
    • cartilage development ^[16]
    • cerebellar granule cell differentiation ^[8]
    • establishment of cell polarity ^[7]
    • limb development ^[16]
    • positive regulation of canonical Wnt receptor signaling pathway ^[10]
    • positive regulation of synapse assembly ^[8]
    • positive regulation of transcription, DNA-dependent ^[10]
    • regulation of axon diameter ^[8]
    • regulation of axonogenesis ^[8]
    • satellite cell activation ^[7]
    • satellite cell maintenance involved in skeletal muscle regeneration ^[7]
    • somatic stem cell division ^[7]
  • is located in the following cellular components:
    • cell surface ^[13]
    • extracellular matrix ^[13]
• Researchers have inferred, based on physical interactions, that the gene product of Wnt7a
  • performs the following molecular functions:
    • frizzled binding ^[7]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Wnt7a
  • participates in the following biological processes:
    • dorsal/ventral pattern formation ^{[5, 11]}
    • embryonic forelimb morphogenesis ^[12]
    • forelimb morphogenesis ^[12]
    • hindlimb morphogenesis ^[12]
    • negative regulation of apoptotic process ^[4]
    • oviduct development ^[6]
    • regulation of cell proliferation ^[4]
    • reproductive structure development ^[12]
    • response to estrogen stimulus ^[4]
    • skeletal system morphogenesis ^[12]
    • skin morphogenesis ^[12]
    • somatic stem cell maintenance ^[7]
    • synapse organization ^[3]
    • uterus development ^{[4, 9]}
    • uterus morphogenesis ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Wnt7a
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway based on interactions with Wnt7b ^[14]
    • central nervous system vasculogenesis based on interactions with Wnt7b ^[14]
    • embryonic forelimb morphogenesis based on interactions with En1, Lrp6 ^{[2, 5]}
    • embryonic hindlimb morphogenesis based on interactions with Lrp6 ^[2]
    • embryonic limb morphogenesis based on interactions with , dblr ^[1]
    • neurotransmitter secretion based on interactions with Dvl1 ^[3]
    • non-canonical Wnt receptor signaling pathway based on interactions with Fzd7 ^[7]
    • synapse organization based on interactions with Dvl1 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Wnt7a:
  • participates in the following biological processes:
    • activation of JUN kinase activity
    • anterior/posterior pattern specification
    • axis specification
    • canonical Wnt receptor signaling pathway
    • cell proliferation in forebrain
    • embryonic axis specification
    • embryonic digit morphogenesis
    • embryonic forelimb morphogenesis
    • embryonic hindlimb morphogenesis
    • negative regulation of neurogenesis
    • negative regulation of transcription from RNA polymerase II promoter
    • palate development
    • positive regulation of cell proliferation
    • positive regulation of epithelial cell proliferation involved in wound healing
    • positive regulation of JNK cascade
    • positive regulation of synapse assembly
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-dependent
    • stem cell development
    • Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells
  • performs the following molecular functions:
    • cytokine activity
    • frizzled binding
    • receptor agonist activity
    • receptor binding
  • is located in the following cellular components:
    • extracellular space
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Wnt7a encodes a protein or proteins that contain the following InterPro domains: Wnt, Wnt protein, conserved site, Wnt-7 protein, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Wnt7a indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Adamska M et al. (2004) En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol, 272:134-44. (PubMed:15242796)
2. Adamska M et al. (2005) Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb. (Erratum: 2005; 233:1614) Dev Dyn, 233:368-72. (PubMed:15880584)
3. Ahmad-Annuar A et al. (2006) Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol, 174:127-39. (PubMed:16818724)
4. Carta L et al. (2004) Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth. Biol Reprod, 71:444-54. (PubMed:15070830)
5. Cygan JA et al. (1997) Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development, 124:5021-32. (PubMed:9362463)
6. Kobayashi A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development, 131:539-49. (PubMed:14695376)
7. Le Grand F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell, 4:535-47. (PubMed:19497282)
8. Lucas FR et al. (1997) WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev Biol, 192:31-44. (PubMed:9405095)
9. Mericskay M et al. (2004) Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development, 131:2061-72. (PubMed:15073149)
10. Ohira T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A, 100:10429-34. (PubMed:12937339)
11. Parr BA et al. (1995) Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature, 374:350-3. (PubMed:7885472)
12. Searle AG. (1964) The genetics and morphology of two 'luxoid' mutants in the house mouse Genet Res, 5:171-197.
13. Smolich BD et al. (1993) Wnt Family Proteins Are Secreted and Associated with the Cell Surface Mol Biol Cell, 4:1267-1275. (PubMed:8167409)
14. Stenman JM et al. (2008) Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science, 322:1247-50. (PubMed:19023080)
15. Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem, 267:4300-11. (PubMed:10866835)
16. Woods CG et al. (2006) Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Am J Hum Genet, 79:402-8. (PubMed:16826533)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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