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Gene Ontology Classifications
wingless-type MMTV integration site family, member 7A

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GO curators for mouse genes have assigned the following annotations to the gene product of Wnt7a. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Adamska M et al. (2004) En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol, 272:134-44. (PubMed:15242796)
  2. Adamska M et al. (2005) Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb. (Erratum: 2005; 233:1614) Dev Dyn, 233:368-72. (PubMed:15880584)
  3. Ahmad-Annuar A et al. (2006) Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol, 174:127-39. (PubMed:16818724)
  4. Carta L et al. (2004) Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth. Biol Reprod, 71:444-54. (PubMed:15070830)
  5. Cygan JA et al. (1997) Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development, 124:5021-32. (PubMed:9362463)
  6. Daneman R et al. (2009) Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A, 106:641-6. (PubMed:19129494)
  7. Kobayashi A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development, 131:539-49. (PubMed:14695376)
  8. Le Grand F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell, 4:535-47. (PubMed:19497282)
  9. Lucas FR et al. (1997) WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev Biol, 192:31-44. (PubMed:9405095)
  10. Mericskay M et al. (2004) Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development, 131:2061-72. (PubMed:15073149)
  11. Ohira T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A, 100:10429-34. (PubMed:12937339)
  12. Parr BA et al. (1995) Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature, 374:350-3. (PubMed:7885472)
  13. Searle AG. (1964) The genetics and morphology of two 'luxoid' mutants in the house mouse Genet Res, 5:171-197.
  14. Smolich BD et al. (1993) Wnt Family Proteins Are Secreted and Associated with the Cell Surface Mol Biol Cell, 4:1267-1275. (PubMed:8167409)
  15. Stenman JM et al. (2008) Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science, 322:1247-50. (PubMed:19023080)
  16. Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem, 267:4300-11. (PubMed:10866835)
  17. Woods CG et al. (2006) Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Am J Hum Genet, 79:402-8. (PubMed:16826533)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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